2017 - On Medicine

Cost-effectiveness of ERT in adult patients with Pompe disease

19/12/2017 Tim Kanters

The number of orphan drugs, i.e. drugs for rare diseases, is vastly growing. These drugs are often associated with high drug prices. Cost-effectiveness studies can be used to examine the ratio of incremental cost and effects of a new intervention. Tim Kanters and colleagues recently published a cost-effectiveness study of enzyme replacement therapy for adult patients with Pompe disease, an orphan disease, in Orphanet Journal of Rare Diseases.

Medicine

Granatum: the user-friendly web tool for single cell RNA sequencing analysis

07/12/2017 Lana Garmire

Here Dr Lana Garmire describes her new tool to analyze scRNA-seq data, published in Genome Medicine.

Medicine

Keeping up with the ISRCTN registry: How much do you know about trial registration?

04/12/2017 Mairead Weir

The ISRCTN registry has continued to change and evolve since its launch in the early 2000s and now has over 16,300 records. ISRCTN keeps adapting to evolving guidelines and expectations in order to support transparency in clinical research, reduce selective results reporting and ensure an unbiased evidence base. Find out how with our ISRCTN registry quiz!

Medical Evidence Medicine

CRISPR/Cas9 gene editing can be used to eliminate entire chromosomes: a Q&A

04/12/2017 Hui Yang

In this Q&A, Hui Yang discusses his research published in Genome Biology, using CRISPR/Cas9 gene editing techniques to delete entire chromosomes, which may have implications for future therapeutics and our understanding of aneuploidy in tumorigenesis.

Medicine

Advances in Simulation: Research Highlights from SESAM 2017 – Paris

30/11/2017 Gabriel Reedy

The 23rd annual meeting of the Society in Europe for Simulation Applied to Medicine (SESAM) took place in Paris this year. Advances in Simulation Editorial Board member Gabriel Reedy talks us through some of the highlights from the conference and introduces the abstracts selected for publication in the journal.

Medicine

A better approach to talent identification?

Usain Bolt wins the men’s 100m final the Beijing Olympics, 2008

30/11/2017 Craig Pickering

Identifying future Olympic champions at a young age is a difficult task, demanding an increasing amount of resources. New research published in Sports Medicine – Open discusses how physical adaptation to exercise is partially genetically mediated, meaning we may be able to identify individuals with the greatest capacity to improve through genetic profiling. Here, lead author Craig Pickering discusses what this means for talent identification programs.

Medicine

Rare variants of RAB10 gene could be key in Alzheimer’s disease resilience

29/11/2017 John Kauwe

In the last decade several genetic risk factors for Alzheimer’s disease have been found by comparing cases with normal controls. Unfortunately discoveries of these gene variants have so far failed to lead to effective therapies. Now, in a research article published in Genome Medicine, researchers have taken the opposite approach by examining elderly people with a high risk of for Alzheimer’s disease who remain cognitively healthy. They find that rare variants in the RAB10 gene may provide protection from the disease.

Biology Medicine

HIV cure – what does it mean?

27/11/2017 Andrew Lever

In support of World AIDS Day 2017, one of the Editors-in-Chief of Retrovirology, Dr Andrew ML Lever, discusses the possibilities and complexities of a cure for HIV.

Medicine

Are inpatient care beds really the answer to the opioid epidemic?

21/11/2017 Jeffrey Samet

A recent commentary in Addiction Science & Clinical Practice argued for a change in how we think about treatment for patients with Opioid Use Disorder (OUD). Editor-in-Chief Jeffrey Samet discusses this important issue with author Peter Friedmann.

Health Medicine

Philosophy matters in medicine

16/11/2017 Roberto Garbero

World Philosophy Day was introduced in 2002 by UNESCO, among other things, to raise public awareness of the importance of philosophy in the choices arising for many societies from the effects of globalization or entry into modernity. We decided to ask Prof. James Giordano and Prof. G. Kevin Donovan, Editors-in-Chief of the journal Philosophy, Ethics,… Read more »

Medicine

Yearly Archives: 2017

In support of World AIDS Day 2017, one of the Editors-in-Chief of Retrovirology, Dr Andrew ML Lever, discusses the possibilities and complexities of a cure for HIV.