Bipolar disorder (BD) formerly known as manic-depressive illness is a mood disorder that is characterized by severe swings of elated behaviour termed mania and deep depression. The etiology of the disorder show a large genetic component with recent studies suggesting gene-environment interactions are important. The World Health Organization (WHO) indicate that bipolar disorder is the… Read more »
In an exciting research article published today in Genome Medicine, Andrew Teschendorff and colleagues provide evidence that the risk of cancer can be predicted by analyzing DNA methylation patterns in cells collected years in advance of the onset of disease. Their approach could provide the basis for a new clinical test with the ability to… Read more »
1Cognitive decline, ranging from mild cognitive impairment to dementia, is an increasing problem in the elderly. There are 36 million people worldwide living with dementia; this is estimated to rise to 100 million by 2050 as the number of people over the age of 65 increases. It has previously been shown that high levels of… Read more »
Experimental Hematology & Oncology has published its inaugural articles. Amongst these are an editorial by Editors-in-Chief Zihai Li and Delong Liu, and Deputy Editor Chung-Tsen Hsueh which highlights the need for the publication of negative research results. The launch articles also include original research on the effectiveness of oxidative stress and redox regulating enzymes in… Read more »
Stem Cell Research & Therapy invites the submission of original research manuscripts for inclusion in a special series on stem cell research in the Asia-Pacific region, to be published later in 2012. The series is edited by Oscar Lee (National Yang-Ming University, Taiwan), Songtao Shi (University of Southern California, USA), Yufang Shi and Ying Jin… Read more »
It’s estimated that around 15 million people suffer from a food allergy in America alone, and the incidence of this global problem continues to grow. Many programs, such as the Food Allergy Initiative and the Food Allergy & Anaphylaxis Network, have been set up to support sufferers and their families, and fund research into this… Read more »
Lung cancer is the second most common type of cancer in the UK, with 38,000 people being diagnosed each year. Biological therapies that target the epidermal growth factor (EGF) receptor are used to treat lung cancer in a subset of patients with EGF receptor mutations. These EGF receptor inhibitors, including afatinib, cetuximab, gefitinib and erlotinib,… Read more »
2Critical Care has just published two new collections to coincide with the start of the 32nd International Symposium on Intensive Care and Emergency Medicine (ISICEM). All articles in both collections are free to access. The first collection, poster abstracts from the 32nd ISICEM are published as a supplement to the journal. Click… Read more »
Neurological conditions encompass a wide spectrum of disorders such as dementia, degenerative diseases, neuromuscular disease, epilepsy and migraine. Treatment options for many neurological conditions can prove to be complex due to high variability between patients of the same disease. Additionally, diagnosis of many conditions, such as migraine is still a topic of much debate, and… Read more »
Early pregnancy loss (EPL), or miscarriage, occurs in around one in four pregnancies. The most common causes of EPL are genetic, including embryonic chromosome abnormalities and DNA mutations in the sperm or egg. Other causes include maternal hormonal disorders such as polycystic ovary syndrome, infections and anatomical abnormalities affecting the mother’s reproductive system. EPL that… Read more »