Trials, they are a’changin’


Genomic advances and their impact on clinical trial design”, a Commentary published this week in Genome Medicine, discusses the effect current advances in genomic research have on the future of clinical trial design and on the interpretation of clinical trial data for disease management.

In their article, Dr Sumithra J Mandrekar and Dr Daniel J Sargent highlight milestones in genomic advances, such as the ability to develop genomic signatures for risk stratification of patients with various diseases and the development of biomarkers indicating how a particular patient might respond to treatment.

Although these advances have been hugely beneficial to medical research, their increased validity has given cause for a whole new way of designing clinical trials in future. For example, past clinical trials aiming to identify diagnostic markers of disease would select participants with certain risk factors for a particular disease and compare their diagnosis to a control group; the identification of genomic signatures, however, would significantly change the identity of risk factors in this trial methodology.  

As is highlighted in this Commentary, we are entering an era of personalized medicine, and advances in genome medicine have provided researchers with a whole new set of tools for studying patient response to treatment; how these tools will best be incorporated into future trial design, however, remains to be seen.

Genome Medicine, BioMed Central’s premier medical journal, stands at the forefront of research and clinical practice in the post-genomic era. The journal is led by six Section Editors and is supported by a world renowned Editorial Board.

We welcome cutting-edge genomic and post-genomic research reporting findings that significantly advance our understanding and management of human health and disease.

Keep abreast of recent developments in these exciting times: register for article updates and submit your next manuscript of outstanding research to Genome Medicine.

Jasmine Farsarakis
Commissioning/Development Editor, Genome Medicine

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One Comment

pamela momodu, trainee biomedical scientist

I am glad that new research and Clinical trails are moving in to an era of Customised Medicine, where risk groups can have treatment or diagnosis tailored to suit their specific Health needs.

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