Dynamic prediction models: Learning to forget
Data on healthcare outcomes, patient populations, and new treatment options are constantly changing over time. Shouldn’t the data used to create our… Read more »
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Medical Evidence
Latest Medical Evidence posts
Global Patient and Public Involvement Network: The vision and mission
Patient and public involvement in health research is now happening across the world1,2,3. Not only do patients and the public have a right to be… Read more »
More Medical Evidence posts
Know your status: World AIDS Day 2018
The theme of World AIDS Day 2018 is “know your status.” To mark the occasion, we at ISRCTN have compiled some of the most… Read more »
Improving sample size calculation and reporting for randomized trials with DELTA² guidance
A key step in designing a randomized trial is choosing the sample size. Too small and the study is underpowered, too large and you… Read more »
How can we improve young people’s mental health in a changing world?
Today is World Mental Health Day, which this year focuses on the theme of "young people and mental health in a changing world". In… Read more »
Prospective registration among trials published in specialty society journals: We can do more to promote transparency and research integrity
Prospective trial registration aims to detect and prevent selective reporting and publication bias. A study published today in… Read more »
CONSORT-SPI 2018: announcing an extension for randomized controlled trials of social and psychological interventions
Complete and transparent reporting of randomized controlled trials is integral for replication, critical appraisal and… Read more »
Why study registration is important for the future of research
Research has played a major role in the history of the NHS over the last 70 years: through development and evaluation, to research… Read more »
Prediction models: how (not) to make them work in clinical medicine
When developing a prediction model to use in clinical medicine, the implementation of this model can often be an afterthought. To… Read more »
Clearer guidance needed for pilot and feasibility studies
With a movement towards feasibility and pilot work in public health interventions, the need for clearer guidance on how best to… Read more »