Genome Medicine has published the first in a series of articles on “Proteomic applications in medicine”, guest edited by Sabine Bahn and Paul Guest (Cambridge University). The series aims to highlight progress and challenges in using proteomic techniques in order to gain clinical insight into disease establishment, progression, diagnosis and prognosis. Genome Medicine is now accepting research or methodology article submissions for inclusion in the series.
Guest et al. describe the technological advancements allowing biomarker research to move from discovery to validation, and eventually to the clinic in an introductory Editorial to the series. The importance of studying co-morbidities, and co-development of biomarkers with drugs is discussed.
Also in this issue, Stuart Cordwell and …
The Human Leukocyte Antigen (HLA) is the most polymorphic region of the genome, with a key role in the immunological response. In humans, HLA genes are contained within the major histocompatibility complex (MHC) locus, consisting ofmore than 200 genes located on chromosome 6. Determining individual HLA types is of critical importance in many aspects of medicine, including transplantation, where donor and recipient tissue types must be matched in order to avoid rejection.
The enormous genetic heterogeneity of this region poses significant challenges in HLA typing. Traditionally, HLA typing has been performed using either serological testing (using white blood cells), or DNA testing (extracting DNA from the white blood cells), and relies upon amplification of the …
The application of proteomic technologies to clinical specimens has the potential to revolutionize the treatment of many diseases. From biomarker discovery and validation to personalized therapies, proteomic techniques allow a greater understanding of the dynamic processes involved in disease, increasing the power of prediction, diagnosis and prognosis.
The editors of Genome Medicine are now accepting submissions of Research, Method, Database, Software and Open Debate manuscripts for an article collection on proteomic applications in medicine, scheduled to begin publication in early 2013. Publication of these articles will be coordinated with a series of commissioned reviews and opinions, edited by Sabine Bahn and Paul Guest (University of Cambridge, UK).
We welcome submissions across the field of proteomics including
• Biomarker …
The pond snail Lymnaea stagnalis has long been used as a model organism in the study of neuroscience. The mollusc’s relatively small neural system and bright orange neurons make it ideal to study the anatomy, molecular biology and electrophysiology of neuronal circuits both in vivo and in vitro, and to further understanding of the effects of this process on behavior.
In a review
published today in Neural Systems & Circuits, Professor Paul Benjamin (University of Sussex) describes studies undertaken in Lymnaea to relate neural circuitry to feeding behaviour. Investigations have revealed the neural networks involved in decision making, biting (a rhythmic process initiated by chemical food stimuli), modulation, hunger and satiety. Interestingly, rather than forming discreet circuits, feeding behaviour …
Duchenne muscular dystrophy (DMD) is a recessive X-linked
form of muscular dystrophy, a neuromuscular condition caused by mutations in
the dystrophin gene. Symptoms of DMD
include muscle degeneration, breathing and walking difficulties, and first
appear in affected children before the age of 5.
The advent of stem cell studies holds much promise for the
treatment and repair of dystrophic muscle in this condition. In an article published in Skeletal Muscle, Parker et al. develop an improved pre-clinical
model of myogenic stem cell transplantation, and test this in both canine-mouse
and canine-canine assays. Previous
experiments using murine-murine transplantation have demonstrated that adult
murine satellite stem cells with engraftment potential in dystrophin deficient
(mdx) mice express CXCR4. In …
In the first in a series of opinion pieces for Neural Systems & Circuits,
David Gamez argues for a greater use of mathematical modelling in order to
study the brain (From
Baconian to Popperian Neuroscience). The piece likens the recent technological
advances in neuroscience with the development of physics in the 17th
century, and suggests that the same principles (e.g. the systematic gathering
of experimental data in order to elucidate the scientific truth) should hold
true in this evolving field.
David states “This
opinion piece argues that the gathering of facts about the brain needs
to be complemented by a greater focus on mathematical models whose
predictions can be experimentally tested. These models …
Neural Systems & Circuits is publishing a special thematic series dedicated to advances in invertebrate circuitry research. The series intends to provide the reader with an overview of new and exciting developments in the field, and will publish reviews and research from key scientists working on diverse model organisms, using either computational or experimental approaches.
For more information on the series, and an introduction to the work featured, please see the recently published Editorial written by Prof. George Kemenes. The first review, published by Prof. Malcolm Burrows, concentrates on the circuitry of phase change in the locust. Further contributions on …
BioMed Central is pleased to announce the launch of a new open
access journal today, Neural
Systems & Circuits, which will be under the leadership of
Latham and Venkatesh
In the inaugural Editorial, the
co-Editors-in-Chief explain the need for a journal that encompasses all aspects
of circuit or systems level analysis, as the distance between theoretical and
experimental studies in neuroscience diminishes. It is hoped that this
journal will foster communication between these two disciplines, allowing for a
greater understanding of the circuitry of the brain. To this end, theory
papers will feature an introductory summary for the non-theorist.
The first articles published in Neural Systems & Circuits …
Biotechnology for Biofuels recently launched its own blog, to provide an additional communication forum for biofuels researchers.
The blog will feature news, comment and opinion relating to the latest developments in biofuels
research, and has just published its first post ‘Biofuels
policy: Public debate and scientific review’.
To stay up-to-date with the latest biofuels research, you can take advantage of RSS feeds both for the latest articles from Biotechnology
for Biofuels, and for the latest blog postings. To receive the latest research by email, don’t forget that you can also register to receive article alerts.
We are delighted to announce the launch of a new, open-access journal,
overseen by Editors-in-Chief Michael Himmel, Bärbel Hahn-Hägerdal, Chris Somerville, and Charles
Wyman, and supported by an international Editorial Board. Biotechnology
for Biofuels emphasizes
understanding and advancing the application of biotechnology and synergistic
operations to improve plants and biological conversion systems for the
production of fuels from lignocellulosic biomass and any related economic,
environmental and policy issues. For
more information, please read the journal’s launch editorial.
Biofuels features the latest
cutting-edge research in the field, reviews and commentary articles from both
Academia and Industry, and will run also operate blog, covering the latest aspects of developments in biofuels. Why not submit your next