Almost three long months of climbing, clinical research, highs and lows came to an end for the Xtreme Everest 2 team last Thursday. The celebration party in Kathmandu, Nepal, was held six years to the day of the successful summit by the 2007 Caudwell Xtreme Everest expedition team, which involved many of the group who were part of this crew.
The Xtreme Everest 2 team explored the well-known ability of Sherpas to tolerate hypoxia – reduced oxygen – at high altitude. 64 Sherpas and more than 100 lowlanders, mainly from the UK, were studied over two months. The scientific agenda focused on microcirculatory and mitochondrial function, nitrogen oxide biology and epigenetics.
A slideshow of …
Two months into a research expedition to Mount Everest, Extreme Physiology & Medicine Editor-in-Chief Mike Grocott, reports from the trip. Researchers on the Xtreme Everest 2 expedition are comparing Sherpa and “lowlander” physiology.
The Sherpas are a group known to perform extraordinarily well at altitude. The team record the physiological responses of healthy individuals in this extreme environment – low oxygen levels at high altitude – and apply this research to patients in intensive care. This is very much in line with the Extreme Physiology & Medicine’s objectives, outlined in its launch editorial, to explore boundary physiology and translate research findings into a clinical setting.
Mike provided this update:
“All our recruited subjects have now been …
The best biographies are autobiographies. Thus, Hugh Montgomery and Mike Grocott, Editors-in-Chief of Extreme Physiology & Medicine, have commissioned a series of career perspectives from research experts in the field. These short personal reviews are written by eminent academics discussing their life’s work and influences so far.
First to reflect on a career’s worth of experience are Jim Milledge, Mike Sawka and John West.
Jim Milledge’s interest in high altitude began as a child, hill walking in Snowdonia. Combining research with clinical medicine in his day job, his career was interspersed with expeditions to study the effects of altitude on various aspects of human physiology.
Among those that influenced him, Jim …
The Signal Transduction Society (STS) has partnered with BioMed Central to publish Cell Communication and Signaling (CCS) for nearly five years.
Since 2010, the “STS/CCS Honorary Medal” has been awarded each year at the annual scientific meeting of the STS. This year’s award was presented yesterday to Carl-Henrik Heldin (Ludwig Institute for Cancer Research, Sweden) in recognition of his major contributions to the field of signaling research. Carl-Hendrik is particularly known for his important work on the PDGF receptor.
Among keynote speakers at this year’s STS meeting was Stephan Feller, Editor-in-Chief of CCS. The special focus of this year’s meeting, tumor biology, has been of interest to Stephan since his doctoral research.
Throughout the years of partnership …
Macrophages influence blood vessel development during growth or tissue repair, and also during tumorigenesis. They are of increasing interest to angiogenic researchers and thus the basis of a new thematic series in Vascular Cell.
The importance of macrophages due to their close physical association with blood vessels is highlighted in an introductory editorial, “Large eaters” meet blood vessels: a new thematic series on macrophages and angiogenesis.
Experts already working in this emerging field have published the following articles in the ‘Macrophages and Angiogenesis’ thematic series:
Macrophages and angiogenesis: A role for Wnt signaling
Myeloid cells in tumor inflammation
Deciphering the roles of macrophages in developmental and inflammation stimulated lymphangiogenesis
Researchers in this field are encouraged to submit their work …
When, in the early 1770s, Joseph Priestley conducted his bell jar experiments with mice and mint plants, could he have imagined that these experiments would be repeated over 200 years later with a human subject? Well, they have been! ‘A paradigm of fragile Earth in Priestley’s bell jar‘ is among the first articles to be published in Extreme Physiology & Medicine.
Exploring how the body functions at the limits of survival, and then applying this research to enhance knowledge of pathophysiology in the critically ill, is a core mission of the new open access journal. It will focus on integrative human physiology …
Over the last few weeks the world’s eyes have been on London. Athletes from around the globe have been striving to achieve their ultimate potential in the sporting events they’ve trained to their limits for.
Among the research published in Extreme Physiology & Medicine, a new open access journal launching in September, will be articles that address the physiological and medical implications of exposure to intense or endurance exercise. This research has the potential to maximise the chances of future Olympic athletes to ‘Go for Gold’.
For some children, this chance is denied them before they even reach the age of two. Nutritional insecurity leads to stunted growth and affects physical ability. The …
The Bibliotheca Alexandrina emulates the Ancient Library of Alexandria as a major centre for scholarship and dissemination of knowledge. It is in this spirit that the Library organises the biennial BioVisionAlexandria meeting, bringing together distinguished speakers, including Nobel Laureates, from around the globe.
The ideology of BioVisionAlexandria 2012 is reflected in our vision for Agriculture & Food Security. Thus, the meeting seemed the perfect setting to celebrate the journal’s recent launch, which was marked by a session at the meeting chaired by one of the Editors-in-Chief, Malcolm Elliott, on ‘Towards Global Food Security: The 21st Century Challenge’.
Editorial board member Nina Fedoroff – current President of the American Association for the Advancement of …
According to the United Nations’ Demographers, the global population exceeded seven billion at the end of October 2011. Ensuring sustainable food production to provide adequate sustenance and nutrition for everyone therefore continues to be a matter of significant and urgent import.
In March, the Commission on Sustainable Agriculture and Climate Change published their report on ‘Achieving Food Security in the Face of Climate Change’. The international Commission of experts, chaired by Sir John Beddington FRS, recommended seven key policy changes and actions that are needed in order to achieve food security in the face of climate change.
One of the Commissioners, Molly Jahn, joins with Malcolm Elliott and Magdy Madkour as a joint Editor-in-Chief of …
Nandita Quaderi and I (Fiona Pring) recently joined some of our Springer colleagues on an engagement tour through Brazil. Both BioMed Central and Springer are committed to helping Brazilian researchers bring their work to the attention of the international community, and to this end Springer opened an office in São Paulo early in 2011, providing a base as well as local contacts for all our initiatives in Brazil.
During our trip, we participated in author workshops at Universidade Federal de São Paulo, Fundação de Amparo à Pesquisa do Estado de São Paulo and Universidade Federal do Rio de Janeiro, where we provided attendees with information about open access publishing, including the benefits to the individual researcher, in a presentation …