In Spring/Summer 2014, Genome Medicine will publish a special issue focusing on Cancer Epigenomics, guest edited by Stephan Beck (University College London).
Large-scale sequencing and high-throughput ‘omic studies of a wide variety of cancers have revealed epigenomic variations, including DNA methylation, histone modification and mutations in genes involved in epigenetic regulation. These have provided mechanistic insights into cancer initiation and progression, and are revealing novel approaches and targets for therapeutic intervention.
This special issue aims to bring together translational findings in cancer epigenomics that have the potential to inform new approaches for screening, diagnosis, prevention and treatment of cancer.
The editors are now accepting submissions of Research, Method, Database, Software and Open Debate manuscripts. The deadline for …
With great fanfare comes great cynicism, and so it should: science is built on the tug-of-war between novel claims and kneejerk skeptism, and the probity that follows. When a sound bite leaked out of last year's ENCODE publications, of which Genome Biology was a participatory journal, that '80% of the human genome has a function', evolutionary biologists were cynical all right, and they took to the journals to say so.
While some of the disagreement hinged on the semantics of the word 'function', a key sticking point was the scientific validity of declaring a stretch of the genome functional when there is no evidence for evolutionary constraint on its constituent DNA sequence. In other words, how …
Launching today with BioMed Central is Basic and Clinical Andrology, a continuation of the French journal Andrologie, which was previously published as a subscription journal by Springer in French. The journal will now be open access and published in English. In keeping with its French past the journal will also publish the abstracts of articles in the French language, just as many other BioMed Central journals that support multilingual abstracts.
Andrology is the field of medicine that covers male health, specifically for problems relating to the male reproductive system. Basic and Clinical Andrology will cover all aspects of male reproductive and sexual health in both human and animal …
Guest blog post by Professor Mike McConnell, Stanford University School of Medicine, USA.
Chemotherapy can injure heart muscle, leading to heart failure, but this damage may not be apparent until many years later. Children receiving chemotherapy are of particular concern, as the risk of heart failure increases as they age into adulthood. A safe, noninvasive method to detect this damage could identify high risk patients and prompt earlier preventive therapy.
In an article published today in Journal of Cardiovascular Magnetic Resonance, researchers from the University of Alberta, Canada present their result from a study looking at MRI of the heart in 30 children two years after chemotherapy. They found changes in the heart muscle even though overall …
June is Cancer Immunotherapy Awareness Month, an initiative to increase the public’s awareness of the revolutionary new treatment approach. Cancer immunotherapy utilises the immune system to fight the disease and represents the most immediate hope for curing patients with any type of cancer. BioMed Central and the Society for Immunotherapy of Cancer (SITC) are therefore pleased to announce the timely launch of the Journal for ImmunoTherapy of Cancer (JITC), an open access, peer reviewed journal that encompasses all aspects of tumor immunology and cancer immunotherapy, from basic research through to clinical applications.
As the official journal of SITC, JITC will be the cancer immunotherapy community’s prime forum to discuss the critical issues in tumor immunology and cancer …
Clinical oncology in Western countries is currently characterized by preventative programs (which include early diagnosis), combined treatments (radio-chemo-surgery), reconstructive surgery, and, more recently, by tailored treatment with monoclonal antibodies or specific inhibitors based on newly identified cancer biomarkers. Clinical oncology in the rest of the world, which represents 85.3% of the Earth’s population, has different priorities, strategies and aims, which are often difficult to compare. Major differences are not only due to the different socio-economical conditions and the national health programs, but also to disparities in cancer burden and their etiopathogenesis, as well the population-based genetic susceptibility. A further major difference is the age-distribution of the population. In the Western world, the population is very much aged, with people aged …
Breast cancer is the most common cancer in the United Kingdom and constitutes the leading cause of cancer-related death in women worldwide. One in eight women can expect to develop breast cancer at some point in their lifetime.
Progress has been made in early detection and treatment of breast cancer but little is understood about how women can reduce their risk of developing the disease. Child-bearing is one factor identified to reduce this risk. If a full-term pregnancy occurs before the age of 20, the risk of developing breast cancer is halved. Yet the mechanism through which this works remains unexplained.
A new publication in Breast Cancer Research uses a novel approach to answer this …
Today sees the launch of Journal of Therapeutic Ultrasound in partnership with the Focused Ultrasound Foundation and the International Society for Therapeutic Ultrasound adding to the growing number of society journals in the BioMed Central portfolio.
Therapeutic ultrasound (also known as focused ultrasound) has the potential to be an alternative or complement for radiation therapy, the means to dissolve blood clots, and a way to deliver drugs in extremely high concentrations to a precise point in the body. It has the potential to treat of a variety of serious medical disorders, including cancer, uterine fibroids, essential tremor, Parkinson’s disease and epilepsy.
Journal of Therapeutic Ultrasound encompasses all aspects of therapeutic ultrasound, namely, …
Head and neck cancer is the sixth most common cancer worldwide, and head and neck squamous cell carcinoma (HNSCC) is the most frequent form. Certain subtypes of HNSCC, such as oropharyngeal carcinoma, are infected with human papillomavirus (HPV), and patients with these HPV-positive tumors have a better prognosis than patients without and respond better to chemotherapy and radiotherapy.
To understand why the HPV-positive patients do better, a team from University College London led by Stephan Beck examined the differences in methylation patterns by sequencing HPV-positive and HPV-negative samples, and the results were recently published in Genome Medicine.
As frozen HNSCC samples are hard to get hold of, the UCL team instead developed a method that …
Franco M Buonaguro and Sam M Mbulaiteye, Editors-in-Chief of Infectious Agents & Cancer, would like to invite you to submit your manuscript to a new thematic series, entitled “Burkitt Lymphoma, Beyond Discoveries” which will be published in the journal.
Burkitt Lymphoma (BL) is an aggressive non-Hodgkin lymphoma (NHL) that was first described by Dennis Burkitt in 1958 in Ugandan children. Since then, numerous breakthroughs, including the discovery of the Epstein-Barr virus (EBV), and its links to the disease, have been made. The most important of these discoveries has been the demonstration of curability of lymphoma which has re-invigorated efforts to use chemotherapy to treat cancer and helped establish some of the key principles of chemotherapy for …