Posts tagged: Cancer

Acetate helps hypoxic cancer cells get fat

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Today’s guest blog is a Cancer Research UK Career Development Fellow, Jurre Kamphorst, a researcher focusing on the metabolic stress responses in cancer cells and lead author of a study published in Cancer & Metabolism.

Unlike normal cells, cancer cells are wired to just keep on growing. This continued growth requires a constant supply of cellular building blocks, including fatty acids for cell membranes. Normally, fatty acids are mostly being made from glucose. However, tumors often face reduced oxygen levels (hypoxia), causing glucose to be only partially metabolized and secreted as lactate, instead of being used for fatty acid synthesis. We discovered that acetate substitutes for glucose as a source for fatty acid synthesis in hypoxic cancer cells.

We were initially …

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The 10th NCRI Cancer Conference: disease prevention, patient care and genomic medicine

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Claire Barnard

Having just returned from the 10th National Cancer Research Institute (NCRI) Conference – the UK’s biggest cancer meeting – BMC Medicine takes a look at some key themes and new research presented at the meeting.

NCRI 2014 brought together clinicians, scientists, patients, funders and many other groups in Liverpool to showcase and discuss the latest findings in cancer research.

Cancer risk and prevention

One of the key themes of the meeting was cancer prevention. As highlighted by Peter Sasieni, smoking is the number one cause of cancer, and removing tobacco would substantially reduce the number of people developing cancer. However, Tim Lobstein from the World Obesity Federation explained that after smoking, being overweight is the second most important preventable risk …

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Taking action to overcome breast cancer

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To mark the end of Breast Cancer Awareness Month, guest blogger Katherine Woods, Senior Research Communications Manager at Breast Cancer Campaign tells us more about their research recently published in Breast Cancer Research and the Off-patent Drugs Bill which they are now collaborating on.

Breast Cancer Awareness Month (or ‘BCAM’ to those of us at Breast Cancer Campaign who refer to it on a daily basis, all year round) is unsurprisingly our busiest and most exciting time of year.

In October 2013, with the dedicated hard work of over 100 international experts, we published our second ‘gap analysis’ paper in Breast Cancer Research, which highlighted the gaps in our knowledge which – if filled – would bring the …

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Breast cancer awareness: genes, behaviors and subtypes

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With October in full swing, Breast Cancer Awareness Month is underway to highlight the importance of breast cancer prevention, early detection and prompt treatment. Understanding the risk factors for breast cancer is key for prevention, and in BMC Medicine we take a look at how genetic and environmental factors contribute to the chance of developing the disease.

Can disease risk genes be modified by environmental factors?

While a number of validated genes are known to confer breast cancer risk, increasing evidence suggests that certain behavioral factors, such as alcohol consumption and smoking, are thought to modify the effect of genetic risk markers. In a commentary article published as part of our Spotlight on breast cancer article collection,

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Making multiple changes to lifestyle factors can reduce risk of developing colorectal cancer

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Intestines (cropped)

Deborah Gilbert from Bowel & Cancer Research and Mohamed A Thaha the National Centre for Bowel Research and Surgical Innovation at Queen Mary University of London discuss a recent article published in BMC Medicine in which it has been found that adoption of a combination of five key healthy behaviors is associated with a reduction in the risk of developing bowel cancer.

Colorectal cancer (CRC) is the third most prevalent cancer and the second most common cancer killer. In recent decades, although cancer care has improved and more people survive longer, many CRC cases are still diagnosed at a late stage, when survival is much less likely. For this reason, much attention is now focused on …

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Together we are stronger: charities join forces to support open access

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A consortium of six leading UK medical research charities will support the costs of making research articles from their funded research immediately and freely openly available to scientists, patients, and donors alike, through the recently announced joint Charity Open Access Fund. David Carr of the Wellcome Trust, Sanjay Thakrar of the British Heart Foundation and Matt Kaiser of Leukaemia & Lymphoma Research explain how this new partnership came about.

As charitable funders of medical research, we are dedicated to maximizing the societal benefits that flow from the research we fund. We know that making research publications openly available ensures that the knowledge and data they contain can be more widely accessed, corroborated and used to advance research …

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A new angiogenesis inhibitor targeting multiple tyrosine kinases offers new hope for treating tumors

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Cancercell

A guest blog from co-Editor-in-Chief of Vascular Cell, Jan Kitajewski, in which he discusses the potential of using the newly developed lenvatinib as an anti-angiogenic therapy in the treatment of thyroid cancer.

Blood vessels can be thought to function as do the roots of a tree, acting to nourish both near and far reaches of the living organism. Despite the amazing capacity of blood vessels to keep your tissues healthy, your blood vessels can be diverted toward more insidious purpose. Tumors attract and accept new blood vessels that they recruit from neighboring tissues. This process of tumor angiogenesis acts to assure that the growing tumor is nourished and provides a path for tumor cells to travel to distant sites.

Targeting …

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‘You might as well patent oxygen’ – an unashamedly unbalanced take on Australia’s support for gene patents

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Last year, a rainbow coalition of civil liberties campaigners, cancer patients and eminent geneticists – heck, even Jim Watson! – argued before the US Supreme Court that gene sequences are a product of nature and therefore ineligible for patent protection.

And the Supreme Court replied, in all its refined wisdom:

'Well, duh!'

A nine-to-nothing unanimous decision.

A difference of opinion

But the US has long known that truths held to be 'self-evident' are not always in for a smooth ride, and so we perhaps should not be too surprised – if still perplexed and saddened – to learn that the Australian Federal Court, when faced with the same question, responded: 'um, maybe not'.

I do not pretend to understand what brand of logic could …

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Reading the new map of breast cancer

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Dr Nick Peel of Cancer Research UK on the classification of breast cancer

Research published today in Genome Biology could improve treatments, and the targeting of treatments, for breast cancer. In this guest post, Cancer Research UK’s Dr Nick Peel describes the history of the findings and what they could mean for future research.

Just over two years ago a landmark study took our knowledge of breast cancer to a new level.

An international team of scientists, led by Professor Carlos Caldas and his team at the Cancer Research UK Cambridge Institute, mapped the genetic landscape of breast cancer in unprecedented detail, redefining it as 10 distinct diseases.

But as with many of these vast genetic explorations, the study revealed as much unexplored terrain as it mapped – exposing the complexity …

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Large hypomethylated blocks could be a universal cancer ‘signature’

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Figure 1 Many of the methylation changes at single probes between cancer and normal 
are far from CpG islands. Irizarry et al. Genome Medicine

In this guest post, Dr Andrew Teschendorff of University College London and the CAS-MPG Partner Institute for Computational Biology, Shanghai, examines a new Genome Medicine study.

In an exciting research article published today in Genome Medicine, Rafa Irizzary and colleagues provide evidence for a gradual systems-level deregulation of the epigenome in stages prior to the onset of cancer and which later is seen to progress further in cancer. Thus, these insights could potentially lead to a clinical test with the ability to predict cancer risk in cells that are not yet malignant.

The authors focused on a specific epigenetic mark, known as DNA methylation, a molecular modification of DNA which can regulate the activity of nearby …

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