Announcing the winners of the 2013 Ming K Jeang Award for Excellence in Cell & Bioscience


Congratulations to the winners of the annual Ming K Jeang Award for Excellence in Cell & Bioscience for 2013. The winning papers (below), have been chosen for their innovation, high-quality execution and lasting contribution to the biosciences. The winners are chosen by a committee of internationally renowned Cell & Bioscience Editors, chaired by Dr Chris Lau.


Monoubiquitination of EEA1 regulates endosome fusion and trafficking

Harish N Ramanathan, Guofeng Zhang, Yihong Ye

Cell & Bioscience 2013, 3:24 (23 May 2013)

Dr TC Wu, a judge on the selection panel for the award, has commented on the importance of this research:

“Early endosomal autoantigen 1 (EEA1) is an essential component of the endosomal fusion machinery. The current study demonstrates that EEA1 is subject to …

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Discovery notes – brief research findings, published fast


Most researchers will tell you that, at some point, they have had a bad experience with peer review, which at its worst is a slow, oblique process which “reflects all the civility of being thrown to the lions in the Coliseum.

Since launching in 2006, Biology Direct has always tried to remove causes of frustration with traditional peer-review models, with progressive policies such as including named reviewer reports as part of published articles, and allowing authors to avoid multiple iterations of review by handing back responsibility for the decision on whether to publish, in light of reviewers’ comments (there’s more on this here).

One of the specific questions that Biology Direct Editors identified was how to publish specific discoveries …

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The world’s largest sequenced genome is just the start

World's Biggest Genome? An infographic

Today the genome of the loblolly pine was published in Genome Biology – the largest yet sequenced. This paper is mostly important because the authors made real improvements to the process that scientists use to sequence large and complex genomes like that of the loblolly pine. Because let’s face it, they’re not likely to hold the record for long. Genome sequencing technologies are moving fast and there are hundreds of sequencing initiatives going on.

So, a little defining of terms. Sequencing is when you work out the exact code of DNA bases A,C,G and T that make up a genome. But you can estimate the number of bases in a genome without knowing what they are, so we have lots of …

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The agony of choice: conservation biology and choosing what to save

Image credit: Wikimedia

You’re a conservationist with a list of threatened species and a limited budget. What are you going to save? Pandas or polar bears? Corals or condors? Leopards or leatherbacks? You have little time to deliberate, and you need a rational basis for your decision.

Performing phylogenetic triage

How to advise those in the unenviable position of making these decisions was the focus of a meeting on ‘Phylogeny, extinction risks and conservation’ last week at the Royal Society, where the central issue was how to exercise this kind of “phylogenetic triage” in the face of inevitable biodiversity loss.

We need some way to choose which species will …

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How 1.3 million women are transforming our understanding of lifestyle factors that affect our health

Doctor talking to patient

“The purpose of life is to contribute in some way to making things better.”
Robert F. Kennedy

We’re often told in one way or another that the actions we take can make a difference – voting in elections, turning the light switch off to save energy. If you’re anything like me, then you’ll have had your doubts about just how true that really is. Will I really affect pollution levels and climate change if I don’t own a car? Will my vote in the election really make any difference?

It’s doubts like these that make me grateful for evidence that shows just how much collective power individuals can have. Evidence like the Million Women Study, which has again been in …

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The Zoological Code and online publication


The International Commission on Zoological Nomenclature (ICZN) has published a response to Dubois et al. who have criticised the way online journals have interpreted the zoological Code (the rules you should adhere to if you want to publish zoological species names correctly). BioMed Central’s response is also published, which expands some of the points we made earlier. Nature also commented here. Thanks to the 2012 Amendment to the Code, things have moved on and online journals are now ‘available’ for nomenclature provided the species is registered in ZooBank and certain conditions are met. The crux of the problem seems to be a misinterpretation of the Code for works published after 1999 and …

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The curious bridge between canine and human science

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Repetitive licking can be a symptom of canine compulsive disorder. Image by Flickr user Jimmy van Hoorn.

What have dogs ever done for us?

Humans and dogs have a long history of co-existence and companionship, and our four-legged friends can have a profound impact on our wellbeing in a number of ways.

The company of dogs has long been thought to reduce anxiety and improve health outcomes, to the extent that Florence Nightingale recommended small pets as “an excellent companion for the sick, for long chronic cases especially” (as Professor James Serpell reports).

Animal-human therapeutic interactions are now an established component of modern medical treatment: the Memorial Sloan Kettering Cancer Center has had a dedicated team of therapy dogs for cancer patients since 2007. Alongside this, guide and hearing dogs have been able to provide essential support

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The subway of the brain – Why white matter matters.

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When we think of the brain, our first thought is of grey matter: the squishy yellowy-grey folded tissue that makes up the cortex. But what about the seemingly useless white matter lurking underneath, with its tougher exterior and long pale branches? There’s more to it than meets the eye…

What is white matter?

White matter has taken the back seat in the past. With apparently no use, white matter was ignored whilst grey matter was probed and inspected. It wasn’t long before white matter rose to recognition for its important role in the brain.

But what is white matter? You could refer to it as the subway of the brain – connecting different regions of grey matter in the cerebrum …

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Advances to watch in brain research – a collection of editors’ perspectives


Brain research, in many ways, can be regarded a field still in its infancy, making it ripe for the exaggerated claims, myths and stereotypes that threaten to discredit the value of real scientific progress. To celebrate Brain Awareness Week and shed light on some of the major recent advances that are set to change lives in the years to come, we called upon our neuroscience and neurology editors for their thoughts in response to the following question: ‘What advancements in the past 2 years do you anticipate will have the biggest impact on people’s lives?

From see-through brains to personalised medicine in psychiatry, here is a collection of extracts from their responses, serving to highlight the progress and benefits of …

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Expand your knowledge of kidney health and function for World Kidney Day 2014


What do you know about your kidneys and how they work?  Current statistics show that 1 in 10 people have some form of chronic kidney disease (CKD), and that the prevalence of CKD is increasing dramatically, highlighting a need for greater awareness on a global scale. It is well known that kidney diseases can seriously affect your quality of life and also prove to be fatal, but under-reporting of kidney problems can be an issue as these diseases can go largely undetected. So… do you want to learn more about how to look after your kidneys?

Since its launch in 2006, World Kidney Day (WKD) has served to help increase public awareness in an attempt to reduce the impact …

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