AllBio's workshop on 'reproducibility in research' saw a metaphorical bottle smashed against the bow of The Genome Analysis Centre (TGAC)'s shiny new training facility.
Fueled by hackpads, marker pens and a mountain of tea and biscuits, the workshop (a mixture of research scientists, PhD students, coders, funders and publishers) set about asking the question: 'what are the barriers to reproducible research?'
Group photo (click to enlarge)
Running to stand still
AllBio was established to bring the technology of bioinformatics to a diverse set of biological disciplines, but with this workshop it stepped across to research's flipside: publishing.
Whether data or papers, it is clear that advances in technology have much to offer when it comes to improving …
The Committee on Publication Ethics (COPE) North American Seminar was held in Philadelphia, Pennsylvania, USA this August with a record breaking attendance from across the region of 81 delegates, including myself representing BioMed Central. The focus of the seminar was new technologies and behaviors for identifying publication ethics issues and those present were fortunate to be involved in an engaging and informative program covering a wide breadth of topics including persistent identifiers in the authoring process, linked content, open access and copyright, and a panel discussion on the use of plagiarism checking software and its effectiveness in identifying misconduct.
Publication ethics are vitally important to editors and the scientific community as they are the foundation for the integrity of the published literature. …
Mr Jones shuffled into the room. “Good morning, Mr Jones, please take a seat.”
Obligingly Mr Smith settled himself in the little wooden armchair beside the desk, as the GP reclaimed his position at the computer.
“So what seems to be the problem” enquired Dr Smith, eyes fixed on the computer screened.
Mr Jones stared down at his lap. His bony hands cradled one another. He slowly rubbed his thumbs in a soothing rhythmic ritual as he hesitated with his response.
“How’s your appetite? Have you had trouble sleeping or difficulty getting to sleep?” The drilling questioning had begun.
“Well, I haven’t been feeling myself lately. It’s hard to describe.” He paused. Shuffled his feet and slumped forward slightly, curling himself “I feel like …
Our Health Services Research conference took place last week. Guest bloggers Jay Shaw and Anita Kothari, round up the last day and give us their thoughts on the conference overall.
The final day of the conference started with two thought-provoking speakers who invoked a flurry of twitter activity.
Anne Sales, with the University of Michigan, raised the issue of social influences on implementing evidence-based practices. Such influences have a long history grounded in Rogers’ Diffusion of Innovation theory. A recent scoping review of social network studies in health (Chambers, Wilson, Thompson, Harden) found that most studies are descriptive with little emphasis on the aspects of social networks that can be attributed to patterns of diffusion.
Nevertheless, Anne reminded the audience that no single …
This week a few of us here at BioMed Central are off to Boston for ISCB’s annual ISMB conference and its Special Interest Group (SIG) meetings. First thing’s first: We’ll be giving away cool swag like our new Bruce Lee/Kill Bill inspired GigaScience Open Data tshirts. Our 8GB GigaPanda USB drives will also be making a repeat appearance.
Where can you get these? We’ll be at booths #419 and #420 and would love to chat to you about open peer-review and our journals Biology Direct and GigaScience or some of our informatics journals like BMC Bioinformatics, Journal of Biomedical Semantics, and BioData Mining. GigaScience will be celebrating their second birthday at the meeting, …
Our Health Services Research conference continues at King’s College London with its second day. What did we learn? And, what were the highlights? Guest bloggers, Jay Shaw and Anita Kothari, round up Day 2 with their key moments.
Three thematic sessions organized the day: Implementation Science, Health Economics, Health Human Resources and Health Systems. Here’s a flavour of how the day unfolded:
Anna Gagliardi, a Scientist with the Toronto General Research Institute, spoke about the problem of translating clinical practice guidelines into practice. In particular, successful implementation in the user setting is difficult to achieve. Since those who produce guidelines may not have the resources to focus on implementation, this task often falls to the user. Tools are …
Today at our Health Services Research Conference, Professor Trish Greenhalgh announced her new campaign for Real Evidence-Based Medicine. In this guest post, her fellow campaigner Dr Jeremy Howick writes about why we need a renaissance in Evidence-Based Medicine.
A meeting involving critics and proponents of Evidence-Based Medicine (EBM) took place in September 2013 to discuss how to overcome current problems with EBM.
Led by Trish Greenhalgh, the meeting attendees wrote an editorial that was published last week in the BMJ. The article – Evidence based medicine: a movement in crisis? – argues that the many benefits of EBM have too often been obscured by undesirable and often unintended consequences including:
Misappropriation of EBM by vested interests. These interests …
Our Health Services Research conference kicked off yesterday at King’s College London. But what were the highlights of Day 1? What did we learn? Guest bloggers, Jay Shaw and Anita Kothari, round up the first day with their key moments:
Day 1 was packed full of speakers focused on Health Systems issues. We present some highlights:
Keynote speaker Professor Nicholas May, Professor of Health Policy in the Department of Health Services Research and Policy at the London School of Hygiene and Tropical Medicine, started the day by discussing the relationship between research and policy in today’s climate. He argued that there has been a widespread call for policy evaluation as the way to engage with evidence-based policy making. …
Guest bloggers Jay Shaw and Anita Kothari kick off the 2014 Health Services Research conference with some conversation starters.
Leading up to this conference, Jay Shaw wrote about the importance of connecting with new colleagues for a better understanding of how various disciplines conceptualize problems to health services issues. He also wrote about the need for a globalized perspective regardless of where you actually conduct your research – global forces influence local trends, and vice versa. This perspective involves looking to places you might not typically turn to in the face of complex health challenges. Jay’s arguments for more cross-disciplinarity in our global context was done in the hopes that you might be inspired to reach out and meet new …
Recent developments in genome-editing technologies have turned the biotech industry's dream of mastering nature into a fast approaching reality. Want to change the color of an ear of corn? All you need to do is edit the relevant gene using the CRISPR/Cas system.
But some traits cannot be edited at the genomic level. The three ears of corn above may have strikingly different appearances, but they are genetically identical – varying only in their epigenomes.
Biotech strategies using genome engineering are impotent when it comes to epigenetically regulated phenotypes. Instead, epigenome-engineering tools are called for. And, as participants heard at May's meeting of the London Epigenomics Club, these prophesized epigenome-engineering tools are now a reality.
How to edit …