Pediatric Brain Tumor Mutations are Detectable in Cerebrospinal Fluid

Diffuse midline gliomas are the most common solid tumors in children, and they are difficult to detect and treat. Molecular tools are needed to aid diagnosis and treatment. Here, Dr Saratsis discusses her research, published in Acta Neuropathologica Communications, examining if tumor-associated DNA could be isolated in CSF from children with brain tumors and sequenced for the presence of histone H3 mutations.