Symen Ligthart and his team at the Erasmus University Medical Centre in Rotterdam are looking at DNA methylation and identifying genetic loci that may be associated with these sites. Regarded as the first meta-analysis of epigenome-wide association studies focusing on C-reactive protein (a general marker of inflammation), his team identified 58 sites that are associated with CRP levels in both African-American and European individuals.
Low-grade inflammation forms the basis of many diseases including diabetes, cardiovascular disease, and stroke. It is important, therefore, that we understand the causes of this inflammation. Here, Symen discusses his paper that was published in Genome Biology late last year.