FANTOM (Functional Annotation of
Mouse) is an international collaborative research project initiated and organized
by the RIKEN Omics Science Center in Yokohama, Japan. Previous work from the
FANTOM consortium has focused on identifying the transcribed components of mammalian
cells. FANTOM4 builds on this work, using novel methods to define how these
cellular components are regulated and work together as a biological network
in the acute myeloid leukemia cell line THP-1.
the first FANTOM4 papers to be published in Genome
Biology is a description of a suite of computer
programs from Josee Dostie and colleagues which allow chromatin conformation
signatures to be identified. In the same journal, Alistair Forrest
and colleagues describe EdgeExpressDB,
a new database and associated tools for interpreting biological networks
and comparing large high-throughput expression datasets. Further
work published in BMC
Bioinformatics by John Quackenbush and colleagues outlines two
new data-driven normalization strategies for high-throughput
PCR data. Additional research articles in this
article series will be published over coming months.
The FANTOM4 papers, including three additional companion articles just published
in Nature Genetics, are put in context
by Phil Kapranov’s minireview,
which is also published in the latest issue of Genome Biology.