An article published today in Genome Medicine showcases a new open-source tool which evaluates the genomic profiles of cancer patients in order to identify opportunities for therapeutic intervention. The authors hope that this novel method will help towards establishing prevention medicine more broadly in hospital settings.
With a movement towards feasibility and pilot work in public health interventions, the need for clearer guidance on how best to design, conduct and report such studies is becoming increasingly paramount. Published today in Pilot and Feasibility Studies, a new systematic review of these guidelines finds that there is still substantial work to be done. Here to tell us more is author of the research, Dr Britt Hallingberg.
Precision medicine has the potential to transform drug therapy and patients’ lives. A recent study published in Human Genomics brings us closer to unlocking that potential. Here, the authors discuss how DNA sequencing and can be integrated with novel computational variant assessment methods to improve predictions of drug metabolism and response of individual patients.
Published today in Research Involvement and Engagement a new systematic review finds that less than 1% of published clinical trials contained critical information on patients engaged in the research. Here, the authors explore the possible reasons behind this lack of reporting and how it can be improved.
Over the past few years, the US Food and Drug Administration (FDA) has faced continual pressure to accelerate the review and approval of new drugs, in order to promote innovation and provide rapid access to new treatments for patients with serious life-threatening conditions. As expedited review and approval programs have increasingly been adopted for certain drugs, there have been concerns that certain drugs are being approved on the basis of smaller, shorter, and fewer trials. Our study published recently in BMC Medicine aimed to evaluate one component of clinical trial evidence that informs FDA approval decisions for new drugs: the study outcomes.
In celebration of Clinical Trials Day we’re challenging you with a quiz on recent initiatives to improve trial conduct and reporting, and ultimately reduce waste in research. Take the quiz, share your results and explore what’s underway to maximise the benefits of clinical research.
Interested in what else we are doing to celebrate Clinical Trials Day? Don’t forget to visit our dedicated page.
To celebrate Clinical Trials Day 2018 and as the leaders in the field gather for the Society for Clinical Trials 2018 Conference, Lucy Chubbock, Assistant Editor for ISRCTN and Trials, considers the role of trial registries in the ever-changing landscape of clinical trials.
With the launch of a brand new thematic series in Trials on ‘Big data for randomized trials’, Series Editor Dr Lars Hemkens talks about his vision for the series and why it is so important to gather evidence and insights on this topic at this time.
Dystonia is a little known syndrome which is estimated to affect at least 70,000 people in the UK. For Dystonia Awareness Week (5 May – 13 May 2018), we asked Dr. Ritesh Ramdhani, Editorial Board Member for Journal of Clinical Movement Disorders, to tell us more about dystonia.