Cell Biology and Genetics Research in the Fight Against Breast Cancer

October is Breast Cancer Awareness Month in the United States. In recognition of this, we are proud to highlight some of the amazing research published on both the basic and clinical research fronts in our cell biology and genetics journals. The field of oncology is greatly informed by advances in bioscience, cell death, genomics, and epigenetics. From DNA methylation to programming cell death, researchers are finding new and promising tools to employ in the battle against breast cancer.

Below is a collection of recent articles from our open access journals, organized by primary theme and curated by our journal Editors, encompassing the fields of cell biology and genetics including: BioData Mining, Cell and Bioscience, Cell Communication and Signaling, Cell Death and Disease, Cell Death Discovery, Cellular and Molecular Biology Letters, Clinical Epigenetics, Clinical Proteomics, Hereditas, Human Genomics, Lipids in Health and Disease, and Molecular Medicine.

We look forward to continuing to publish research that will continue to inform diagnostics and treatments in breast cancer, and indeed, all cancers in the years to come.

Breast cancer risk assessment and diagnostics

A new bioinformatics tool to help assess the significance of BRCA1 variants

Development and validation of a variant detection workflow for BRCA1 and BRCA2 genes and its clinical application based on the Ion Torrent technology

Evaluation of nipple aspirate fluid as a diagnostic tool for early detection of breast cancer

Increased epigenetic age in normal breast tissue from luminal breast cancer patients

Iteratively refining breast cancer intrinsic subtypes in the METABRIC dataset

Large-scale analysis of DFNA5 methylation reveals its potential as biomarker for breast cancer

Lipoprotein subfractions by nuclear magnetic resonance are associated with tumor characteristics in breast cancer

miRNAs as potential biomarkers in early breast cancer detection following mammography

Radiotherapy improves serum fatty acids and lipid profile in breast cancer

Systematic identification of the key candidate genes in breast cancer stroma

Breast cancer therapeutics

A Bowman–Birk inhibitor induces apoptosis in human breast adenocarcinoma through mitochondrial impairment and oxidative damage following proteasome 20S inhibition

Are online prediction tools a valid alternative to genomic profiling in the context of systemic treatment of ER-positive breast cancer?

A temporal examination of calcium signaling in cancer- from tumorigenesis, to immune evasion, and metastasis

Bioinformatics-based identification of miR-542-5p as a predictive biomarker in breast cancer therapy

miRNA-205 targets VEGFA and FGF2 and regulates resistance to chemotherapeutics in breast cancer

Phyto-polyphenols as potential inhibitors of breast cancer metastasis

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

The epigenetic modifier JMJD6 is amplified in mammary tumors and cooperates with c-Myc to enhance cellular transformation, tumor progression, and metastasis

Influence of hormones on breast cancer

DNA methylation and hormone receptor status in breast cancer

Integrative genomic analysis reveals functional diversification of APOBEC gene family in breast cancer

Knockdown of LncRNA MAPT-AS1 inhibits proliferation and migration and sensitizes cancer cells to paclitaxel by regulating MAPT expression in ER-negative breast cancers

Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells

Reawakening of dormant estrogen-dependent human breast cancer cells by bone marrow stroma secretory senescence

Signaling pathways in breast cancer

CD146, a novel target of CD44-signaling, suppresses breast tumor cell invasion

H19/let-7/LIN28 reciprocal negative regulatory circuit promotes breast cancer stem cell maintenance

Hedgehog pathway is involved in nitidine chloride induced inhibition of epithelial-mesenchymal transition and cancer stem cells-like properties in breast cancer cells

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis

Role of apoptosis-related miRNAs in resveratrol-induced breast cancer cell death

Sodium butyrate promotes apoptosis in breast cancer cells through reactive oxygen species (ROS) formation and mitochondrial impairment

The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma

TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA

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Rebecca Pearce

Journal Development Manager at BMC

I am currently a Journal Development Manager with BMC overseeing a porfolio of open access journals in the areas of cell biology, genetics, and microbiology. I have worked in academic publishing for more than 13 years and have a MA in animal behavior and conservation.

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