Switched on by coffee? Rafael Franco and colleagues introduce the receptors responsible as members of a huge and diverse family of proteins – G-protein-coupled receptors – that are targeted by many of the drugs in our pharmacies. Their latest findings show how different adenosine receptor subtypes combine to act as a concentration-sensing device, highlighting how novel properties can emerge from different combinations of G-protein coupled receptors, and the potential for targeting these with drugs.
Rare genetic neurodevelopmental disorders are often associated with autism spectrum disorder (ASD). For example, about 30% of individuals with Fragile X syndrome, a rare form of intellectual disability, have autism. In this blog marking Rare Disease Day, Dr. Silvia De Rubeis shares some of the latest research on rare genetic diseases associated with autism and explains how it is benefiting treatment strategies, improving clinical trials and increasing our knowledge of autism.
An article recently published in Molecular Brain explores Ghrelin deficits within Parkinson’s disease. By using disease-specific induced pluripotent stem cells (iPSCs) containing the PARK2 gene mutations, the researchers reveal that a receptor for Ghrelin might be a potential new therapeutic target for the disease.
Prof. Peter Newman, the Editor-in-Chief of BMC’s new journal Sustainable Earth, talks about his motivation for sustainability and the need for a new journal in part 1 of this interview. Special thanks to Linda Blagg at Curtin University for the filming and recording of the interview.
On February 8th and 9th at the United Nations headquarters in NYC, the Royal Academy of Science International Trust held a program to recognize women in STEM fields, and the importance of their presence for the progression of humanity, empowerment of society, and impact on the research currently being pursued. As BMC is a diverse,… Read more »
Through the combination of genomics and metabolomics research, scientists are getting closer to understanding the impact of environmental exposure and lifestyle on disease onset. This recently designated “exposotype” (which takes into account genomic and metabolic data) is a new tool researchers can potentially use to refine and revolutionize current thinking about precision medicine and risk assessment.