Chronic wasting disease found in Norwegian free-ranging tundra reindeer

A new article in Veterinary Research reports on the first case of chronic wasting disease in Europe. Chronic wasting disease (CWD) is a prion disease affecting reindeers and other cervids, and up until now has only been seen in North America. Dr Christina Sigurdson, a specialist in the field, talks here prion diseases and the implications of this finding.

Prion diseases are infectious neurodegenerative disorders of humans and animals caused by the misfolding and aggregation of a normal, cellular prion protein. In an infected individual, the aggregated prion protein builds up into plaques in the brain and spinal cord, causing neuronal loss and eventually leading to death.

Chronic wasting disease prions in North American cervids

Prion diseases in animals include scrapie in sheep and goats, bovine spongiform encephalopathy (BSE) or “mad cow disease” in cattle, and chronic wasting disease (CWD) in cervids, which affects primarily deer, elk, and moose. CWD was first discovered in Colorado deer in 1967, and was believed for decades to be restricted to deer and elk in Colorado and Wyoming.

CWD-infected cervids have been detected in more than 20 additional US states.

Intensive surveillance efforts over the past 16 years have instead revealed CWD in cervids well beyond these two states, as CWD-infected cervids have been detected in more than 20 additional US states stretching from Utah to the eastern seaboard as well as in two Canadian provinces, with prevalences of up to 35% in free-ranging populations and 90% in captive deer – inarguably the most infectious natural prion disease known to date. CWD prions are shed in saliva, urine, and feces; even exposure of naïve deer to an infected animal’s bedding and water bins can transmit CWD prions.

CWD in a reindeer in Norway

In a recent article in Veterinary Research, Benestad and colleagues report the opportunistic discovery of chronic wasting disease in a free-ranging tundra reindeer in Norway, which is a surprising and alarming finding as it now indicates that CWD exists in wild animals in Europe.

A surprising and alarming finding as it now indicates that CWD exists in wild animals in Europe.

The brain of the affected reindeer showed classic histopathologic features of CWD in North American cervids, consisting of intense vacuolation and prion aggregates, particularly in the brainstem. The diagnosis was confirmed by ELISA and immunoblotting for prions, the latter showing prion protein bands characteristic of CWD in elk. A highly significant finding was the presence of prions in lymphoid tissue, which is typical of CWD in cervids and indicative of an extraneural phase of prion replication. The transmission studies ongoing in a panel of transgenic mice will aid in determining whether the Norwegian strain of CWD differs from that of North American cervids.

stain
Figure 1 HE staining shows vacuoles in the neurons and neutrophils

Origin of CWD prions in Norway

A key question is, how did CWD prions arise in a reindeer in Norway? The possibilities include (i) the reindeer was infected with sheep scrapie, which seems unlikely given that extensive scrapie surveillance has not revealed any classical scrapie cases in the region inhabited by the reindeer, although spread from sheep with atypical scrapie cannot be excluded, (ii) CWD introduced from the importation of a CWD-infected animal or animal product, or (iii) sporadic CWD developed in a cervid, which then spread horizontally through the population. This latter possibility is worrisome as it could indicate that epidemics of CWD could arise in any cervid population.

Considering that CWD prions transmit among cervids with high efficiency and infect several species of cervids, European cervid populations may be at high risk for CWD infection.

Considering that CWD prions transmit among cervids with high efficiency and infect several species of cervids, European cervid populations may be at high risk for CWD infection. Additionally, the recent finding of CWD in two moose in Norway noted by Benestad and colleagues suggests that CWD may be widespread and may have existed in Norway for years.

The looming question remains, where is CWD in Europe and beyond, and what cervids and other mammals are susceptible? Are these three CWD-infected reindeer and moose indicative of an isolated geographic focus in Norway, or has CWD already expanded into cervid populations in Sweden, Finland, Denmark, Russia and beyond? Further surveillance of cervid populations is warranted and will help answer these questions.

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