At the Vascular Cell Blog, we do our best to provide you with updates not just on the goings-on here at the journal, but also on important developments and events in the field. Our latest conference announcement is actually three meetings in one, and definitely not something to miss.
The North American Vascular Biology Organization (NAVBO) and the Microcirculatory Society (MCS) are teaming up this October to present a week of seminars, presentations, and workshops on a huge spectrum of topics related to vascular biology. Entitled simply “Vascular Biology 2013“, it will feature keynote presentations from angiogenesis mavens such as Ralf Adams,
Vascular Cell prides itself on its Thematic Review Series, in which eminent investigators contribute review articles on specific foci within the wider field of angiogenic research. In the past, these reviews have discussed angiogenic modulation via nanomedicine, anti-tumor treatment targeting the Dll4/Notch pathway, and the role of angiogenic therapy in cardiovascular disease. Most recently, the series on Macrophages and Angiogenesis summarized the multifaceted myeloid contribution to vascular growth and remodeling.
In its next Thematic Review Series, Vascular Cell will detail the role of
Today we’ll look back over the last month or so in Vascular Cell, and highlight some of the recent developments at the journal.
First off, Maruotti et al. add the fifth article to our Macrophages in Angiogenesis series, with their discussion of the role of macrophages in rheumatic disease. Beyond being mediators of passive immunity, the authors detail how macrophages also promote the pathologic vascularization into the rheumatic joint synovial cavity, which facilitates further immune cell access to the area and aggravates inflammation.
Of course, macrophages have many roles, and the authors point out that some subpopulations may function in an antiangiogenic, and …
So far, the Vascular Cell Blog has been primarily concerned with spreading the word about conferences and symposia in fields related to angiogenesis research. We’ve talked about Gordon Conferences, NAVBO meetings, and a number of other important events. We’ll definitely continue in this vein, but we’re also going to start writing more frequently about other news and developments that impact angiogenesis research, and in particular interesting contributions to the field coming out of the Vascular Cell journal itself.
For the moment, however, it’s conference time again! And it doesn’t get much more relevant or important than this one. The Gordon Research Conference on “Angiogenesis” will take place this year from August 4-9 at …
The last couple of blog entries have focused on distinct non-endothelial components of the vascular milieu, and the effects of these historically under-appreciated elements on blood vessel dynamics. Today we take a slightly different tack, to dwell instead upon a class of enzymes that plays critical roles in many of the key steps of angiogenesis.
Matrix metalloproteases, or MMPs, are essential for degrading the basement membrane surrounding blood vessels in order to allow the outgrowth of new sprouts, and their regulation is critical to both vessel proliferation and stability. In addition, members of the MMP family are also key components of core signaling pathways critical to vascular network formation.
From May …
The lymphatic system often receives less attention than its blood-bearing cousin, but its roles in health and disease are not to be underestimated. Indeed, a great deal of recent research has helped to uncover the subtle physiological forces driving lymphatic development, and has clarified the contribution of lymphatic dysregulation to a host of pathologies, from arthritis to tumor metastasis.
In appreciation of the growing interest in lymph and the vessels that carry it, the North American Vascular Biology Organization (NAVBO) is holding its first meeting focused exclusively on lymphatics this upcoming May.
The meeting is titled “Lymphatic Circulation in Health and Disease”, and will take place in New Haven, Connecticut, in association with Yale University.
Hosted by faculty from …
One of the most important trends in contemporary vascular biology research is our growing understanding of the role of non-endothelial support cells in the vascular milieu. The macrophage is a fascinating, enigmatic component of this microenvironment.
Originally thought to be solely involved in passive immunity, recent research has uncovered roles for macrophages in a host of physiological and pathological processes. They not only perform classic inflammatory tasks, but also secrete pro- and anti-angiogenic factors, guide vascular anastomosis, drive atherosclerotic plaque development, and even guide cancerous cells out of primary tumors towards the vasculature.
Vascular Cell has recently introduced a thematic series entitled “Macrophages and Angiogenesis”. This collection of reviews describes the state of the field in macrophage-related vascular …
The Gordon Research Conference on Vascular Cell Biology will take place from January 27 to February 1, 2013, in balmy Ventura, California.
The conference this year is hosted by Timothy Hla, Weill Cornell Medical College, and co-chaired by Anne Eichman, Yale School of Medicine. It brings together researchers from top institutions across the globe to discuss the most recent developments in diverse areas of vascular research.
For a more complete description, we turn to Dr Hla:
“2013 Vascular Cell Biology GRC will feature cutting-edge research on developmental cues and gradients, stem/ progenitor differentiation into vascular lineages, vascular endothelial and smooth muscle cell interactions with biophysical forces, gases and extracellular matrix as well as inflammatory cytokines and lipid mediators.
The ‘Related clinical trials’ feed on the Vascular Cell homepage provides a clinical complement to all of the basic science research presented by Vascular Cell. It reaches beyond the journal itself to bring news about emerging clinical trials straight to our homepage.
Related clinical trials is an RSS feed from ClinicalTrials.gov. It collects updates on federally reported human trials involving clinical application of angiogenesis-modifying therapies. The majority of studies on the feed are newly announced or newly recruiting patients. This makes it an excellent resource for doctors and patients searching for emerging disease treatment options. For an expanded look at recent clinical developments, you can click the “View More” link at the bottom of the frame to …
Vascular Cell launches a new thematic series on the topic of “Macrophages and Angiogenesis”. This new area of angiogenic research looks at the interplay between tissue and tumor macrophages and the vessels they interact with. The first contributions to this series discuss 1) myeloid cells and the tumor microenvironment, 2) Wnts and angiogenic macrophages, and 3) macrophages and lymphatic vessels.