The maintenance of genomic integrity in response to DNA damage relies on the intricate coordination of DNA repair, cell cycle progression, transcriptional and post-transcriptional regulation and apoptosis. The DNA damage response pathways play a critical role in human health, as failure at any of these steps could lead to cancer and other diseases.
In a collection of reviews published in Cell & Bioscience today, guest edited by Dr Guo-Min Li, we attempt to define the most challenging questions concerning DNA damage response and repair, and to provide an overview of the latest advances in the field.
This is one of a number of exciting special issues to be published in Cell & Bioscience this year. To keep up-to-date with the latest journal content, please do sign up for article alerts.