Posts tagged: Pharmacogenomics

miRNA biomarkers in osteosarcoma: crossing a new bridge

GM logo 1

Osteosarcoma is the most common type of bone tumor, but the lack of good biomarkers to predict the outcome of standard treatment has so far prevented patient stratification and therapy evolution. Gene expression signatures, including microRNA (miRNA) profiles, have been suggested to have predictive value for the response of a tumor to chemotherapy, but the limited availability of frozen tissue samples has hindered development of signatures with prognostic value for recurrence and survival. Formalin-fixed paraffin-embedded tissue (FFPE) is the standard sample used by histopathological laboratories but it has proved very challenging to use this for reliable expression-profiling.

This problem has now been overcome by Dimitrios Spentzos and colleagues, whose study was recently published in Genome Medicine. The …

Read more