Posted on behalf of Helene Faure
Clinical trials have been in the spotlight for a number of months in the UK, from the publications of Dr Ben Goldacre to the launch of the AllTrials campaign to demand public listings of all clinical trials (read an interview in the BioMed Central magazine Biome), from a major Parliament Enquiry to the Health Research Authority – which looks after the interest of trial participants – insisting on timely reporting of trials.
Plainly and simply, there is a general consensus that scientific information and results around clinical trials should be made more accessible and understandable to the general public. Not only research funders and policy makers but publishers have a role to play …
The introduction of digital object identifiers (DOIs) to all ISRCTN records in the Current Controlled Trials database, announced today, is an essential part of achieving the aims of the Threaded Publications initiative – making the medical literature more transparent and better connected.
Prospective trial registration should be the first step in transparently disseminating all scientifically relevant information about a clinical trial. Trials can be very expensive to carry out, involve large numbers of subjects and investigators, and generate large amounts of data potentially constituting several scientific articles. The articles from the third International Stroke Trial are a case in point. But unfortunately many clinical trial-related articles are not published, leading to bias in …
Current Controlled Trials (CCT) has introduced digital object identifiers (DOIs) to all ISRCTN records. DOIs issued by the organisation CrossRef are unique alphanumeric ID assigned to a digital object, such as an electronic journal, article, report, thesis or a clinical trial record. A DOI serves as a stable, persistent link to the full-text of an electronic item on the internet. The journal or article website address can change over time but a DOI is permanent. DOIs are widely used by academic publishers for helping to ensure the permanence, discoverability and citability of scholarly content published on the web.
A trial ID such as the ISRCTN uniquely identifies a clinical trial. Introduction of a DOI (made …
A new Current Controlled Trials (CCT) advisory board has been appointed as of October 2012, whom we are looking forward to working with on guiding the future development of our trial registration and related publishing services.
Some members have been helping us promote and improve the quality of prospective clinical trial registration for many years:
Gerd Antes (German Cochrane Centre), Maurizio Bonati (Mario Negri Institute for Pharmacological Research), Kay Dickersin (Johns Hopkins Bloomberg School of Public Health), Jeffrey Drazen (New England Journal of Medicine), Richard Lilford (University of Birmingham), Elizabeth Wager (Publications consultant) and we thank them for their past contributions, and for renewing their commitment to the service.
Also, we welcome new members who are specialists in designing trials, reporting …
How many trials recruiting in the UK have been publicly registered in 2011? In which disease area is the highest number of registered trials? Which countries apart from the UK are represented in the ISRCTN Register? In answer to those frequently asked questions, the ISRCTN Register, made of over 10,800 records, has launched a page providing some insight on its content. The data is up to the end of June 2012 and the statistics will be updated at regular intervals.
The statistics include a breakdown of the disease areas represented in the ISRCTN Register – top areas include cancer, mental health and cardiovascular trials.
The top countries section illustrates the ISRCTN Register’s collaboration with the Department …