Posts tagged: insomnia

Does insomnia lead to Alzheimer’s disease?


Disruption to sleep patterns is traditionally seen as a downstream symptom of Alzheimer’s disease.

Recent evidence, however, has sparked a debate of whether circadian dysfunction may actually lead to the development of Alzheimer’s disease by causing the accumulation of one of its main pathogens, amyloid-beta (Aβ) in the brain.

Converging research in both animal and human studies has found that the circadian cycle regulates levels of Aβ in the brain, and that acute suppression of sleep increases these levels. The principal hormone of the circadian system, melatonin, which is protective in cells exposed to toxic Aβ, is also seen to be dysregulated in Alzheimer’s disease. This raises the possibility that insomnia in humans could cause toxic Aβ accumulation over time, …

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