Posts tagged: extreme environments

Double celebration for Xtreme Everest 2 expedition

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Muscle biopsy

Almost three long months of climbing, clinical research, highs and lows came to an end for the Xtreme Everest 2 team last Thursday.  The celebration party in Kathmandu, Nepal, was held six years to the day of the successful summit by the 2007 Caudwell Xtreme Everest expedition team, which involved many of the group who were part of this crew.

The Xtreme Everest 2 team explored the well-known ability of Sherpas to tolerate hypoxia – reduced oxygen – at high altitude.  64 Sherpas and more than 100 lowlanders, mainly from the UK, were studied over two months.  The scientific agenda focused on microcirculatory and mitochondrial function, nitrogen oxide biology and epigenetics.

A slideshow of …

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Xtreme Everest 2: exploiting extreme conditions to benefit critically ill patients

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Outside Everest Base Camp Laboratory

Two months into a research expedition to Mount Everest, Extreme Physiology & Medicine Editor-in-Chief Mike Grocott, reports from the trip.  Researchers on the Xtreme Everest 2 expedition are comparing Sherpa and “lowlander” physiology.

The Sherpas are a group known to perform extraordinarily well at altitude.  The team record the physiological responses of healthy individuals in this extreme environment – low oxygen levels at high altitude – and apply this research to patients in intensive care.  This is very much in line with the Extreme Physiology & Medicines objectives, outlined in its launch editorial, to explore boundary physiology and translate research findings into a clinical setting.

Mike provided this update:

All our recruited subjects have now been

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Personal career perspectives in Extreme Physiology & Medicine

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The best biographies are autobiographies.  Thus, Hugh Montgomery and Mike Grocott, Editors-in-Chief of Extreme Physiology & Medicine, have commissioned a series of career perspectives from research experts in the field.  These short personal reviews are written by eminent academics discussing their life’s work and influences so far.

First to reflect on a career’s worth of experience are Jim Milledge, Mike Sawka and John West.

Jim Milledge’s interest in high altitude began as a child, hill walking in Snowdonia.  Combining research with clinical medicine in his day job, his career was interspersed with expeditions to study the effects of altitude on various aspects of human physiology.

John West

Among those that influenced him, Jim …

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Extreme Physiology & Medicine – a new journal launched today!

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When, in the early 1770s, Joseph Priestley conducted his bell jar experiments with mice and mint plants, could he have imagined that these experiments would be repeated over 200 years later with a human subject? Well, they have been! ‘A paradigm of fragile Earth in Priestley’s bell jar‘ is among the first articles to be published in Extreme Physiology & Medicine.

Exploring how the body functions at the limits of survival, and then applying this research to enhance knowledge of pathophysiology in the critically ill, is a core mission of the new open access journal. It will focus on integrative human physiology …

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