New research published today in BMC Medicine shows that Viagra could be used as a safe treatment for heart disease. In this guest post, lead author on the paper, Andrea M. Isidori of Department of Experimental Medicine at Sapienza University of Rome, tells us more about the background to this research and what they found out.
Everybody’s heard of Viagra (sildenafil). It was the first phosphodiesterase type 5 inhibitor (PDE5i) marketed for the treatment of erectile dysfunction. But few people are aware of the other beneficial effects and potential new uses for this class of drugs.
Viagra was originally tested for heart problems – angina pectoris, a chest pain associated with coronary heart disease – on the basis of its vasodilatory …
With October in full swing, Breast Cancer Awareness Month is underway to highlight the importance of breast cancer prevention, early detection and prompt treatment. Understanding the risk factors for breast cancer is key for prevention, and in BMC Medicine we take a look at how genetic and environmental factors contribute to the chance of developing the disease.
Can disease risk genes be modified by environmental factors?
While a number of validated genes are known to confer breast cancer risk, increasing evidence suggests that certain behavioral factors, such as alcohol consumption and smoking, are thought to modify the effect of genetic risk markers. In a commentary article published as part of our Spotlight on breast cancer article collection,
As the global obesity epidemic continues, more and more overweight and obese women are becoming pregnant. It is estimated that around 15-20% of pregnant women in the UK have a body mass index (BMI) higher than 30, which can have serious health consequences for both mothers and their children.
The consequences of obesity during pregnancy
Obesity poses risks to mothers throughout gestation and childbirth, as well as in the postpartum period. During pregnancy, the risk of gestational diabetes and pre-eclampsia is elevated in obese women, and those with a BMI over 30 are more likely to suffer miscarriages and infections. There are also many risks to babies born to obese women, including stillbirth, preterm delivery, congenital …
Deborah Gilbert from Bowel & Cancer Research and Mohamed A Thaha the National Centre for Bowel Research and Surgical Innovation at Queen Mary University of London discuss a recent article published in BMC Medicine in which it has been found that adoption of a combination of five key healthy behaviors is associated with a reduction in the risk of developing bowel cancer.
Colorectal cancer (CRC) is the third most prevalent cancer and the second most common cancer killer. In recent decades, although cancer care has improved and more people survive longer, many CRC cases are still diagnosed at a late stage, when survival is much less likely. For this reason, much attention is now focused on …
To recognize World Mental Health day and its focus on living with schizophrenia we‘ve taken a look at some recent research emphasizing quality of life and treatment for those affected by this chronic mental condition.
Seven adults out of every 1,000 have schizophrenia, with half of affected individuals not receiving appropriate care. Over 90% of untreated people are from low- and middle- income countries. The WHO Mental Health Gap Action Programme (mhGAP) aims to scale up services for mental disorders in these countries by ensuring proper care, psychosocial assistance and medication.
Quality of life
Living with schizophrenia affects daily life. A recent study from the UK, highlighted in the news, showed that delusion prone schizophrenic patients are less likely …
Today is World Heart Day, and having recently got back from attending the European Congress of Cardiology as part of my role at BMC Medicine, it seemed an opportune moment to take you through some of the important findings discussed there.
The World Health Organisation (WHO) has estimated that 17 million people die every year from cardiovascular diseases. However, the majority of these deaths could be avoided by managing risk factors such as tobacco smoking, unhealthy diet, physical inactivity and harmful alcohol use.
To achieve control of these risk factors the WHO and the US Centers for Disease Control and Prevention (CDC) are developing and implementing appropriate policies to tackle the challenges.
The issue of research in cardiovascular diseases in …
Findings from the Turnaway study, which aims to look at the effects of unwanted pregnancy on women’s lives, were published today in BMC Medicine. In this guest blog, Diana Greene Foster, Principal Investigator of the Turnaway study writes about her experiences in leading it.
When we started the Turnaway study, a main goal was to understand the consequences of abortion for women’s lives. A handful of researchers had posited that many women experience ‘post-abortion trauma syndrome’ – mental health disorders caused by having an abortion. Since nearly one out of three women in the U.S. has an abortion over her lifetime, such a syndrome would potentially affect millions of women.
I’m a demographer, so I naturally think about health conditions …
An analysis of the organ donation protocols of 48 countries has been published in BMC Medicine today, studying the differences between opt-in and opt-out systems. In this guest post, Sally Johnson, Director of Organ Donation and Transplantation at National Health Service (NHS) Blood and Transplant, tells us about why we need more people to consent to organ donation.
As director of Organ Donation and Transplantation at NHS Blood and Transplant I’m delighted to have seen huge increases not just in the numbers of deceased organ donors over the last few years, but also in the numbers of patients benefitting from a transplant.
However, I want to explain why we can’t rest on our laurels and why we still have a …
Our guest author, Ali. A. Mokdad is based at University of Texas and affiliated with the Institute of Health Metrics and Evaluation (IMHE). He is the lead author of a recent study published in BMC Medicine, focusing on deaths caused by liver cirrhosis.
Liver cirrhosis is a costly disease that is devastating to families and their finances. Most of these deaths are preventable, however. Countries can reverse the tide of liver cirrhosis by implementing a variety of cost-effective solutions.
When my colleagues and I saw just how many deaths occurred each year as a result of liver cirrhosis, we decided to write a paper to raise awareness about these disease trends and the steps that could be taken …
Malaria is present in over 100 countries worldwide, and it is estimated that around 3.4 billion people – half of the world’s population – are at risk of infection. There were an estimated 627,000 deaths caused by malaria infection in 2012, with over 90% of deaths occurring in African children.
The disease is caused by Plasmodium parasites including P. falciparum and P. vivax, which are carried by infected Anopheles mosquitoes. Antimalarial drugs can be used to prevent and treat malaria, but resistance to these agents frequently develops. Recent research found that P. falciparum parasites are becoming increasingly resistant to artemisinin therapies in Southeast Asia, highlighting that radical action is required to prevent the spread of malaria …