The design principles of cell shape are the main focus of Wallace Marshall’s lab at the Department of Biochemistry & Biophysics, UCSF. As the inaugural contributor to our series on Cell geometry (see: “Origins of cellular geometry”) he discusses in this guest post the role of mathematical modelling and the lessons of physics in the context of a new review article by Fred Chang and Kerwyn Casey Huang “How and why cells grow as rods”, just published in the series.
Predictive models are the difference between alchemy and chemistry. Everyone seems to agree that simple, quantitatively predictive models, of the type seen in physics, are something we should strive for in cell biology.
Just collecting lists of …
In the panel discussion at the end of the first BioMed Central conference on Metabolism, diet and disease, the panellists confronted the overwhelming evidence for a link between obesity and cancer. The panel discussion at the second picked up where the first left off – Can cancer be prevented by diet?
The only categorical answer came from Stephen O’Keefe, starting from the epidemiology that shows a 100-fold difference in colon cancer risk between African Americans (high) and rural Africans (low). If you switch their diets – and he has done the experiment – the gut microbiota, he reports, switches within two weeks, with known carcinogens going up in the guts of the rural Africans and conversely down in African …
For almost thirty years, David Stern has been obsessed with the fact that male fruit flies ‘sing’ to females. His work on this problem, published today in BMC Biology, has got him thinking about reproducibility in science. In this guest post, he sets out his prescription to help scientists check whether research results are reliable
As an undergraduate at Cornell in 1985, I looked for a research problem that combined my interests in genetics, evolution, and behavior. Kyriacou and Hall had recently reported that the period gene, which regulates circadian rhythms, also controlled a rhythm of fruit fly courtship song and that evolution of period explained a species difference in this courtship song rhythm. This seemed …
Inexplicably absent from the current fad for Scandi-dramas is a mystery thriller set among the geysers, glaciers and Guðmundsdóttirs of Iceland.
One compelling candidate for filling this void is Prof Karl Gústaf Kristinsson, a medical microbiologist at Reykjavík's Landspitali University Hospital, and his quest to tell the story of the superbug PMEN2.
The pneumococcal detective
Prof Kristinsson has been on the case of Icelandic varieties of the multidrug resistant pneumococcus PMEN2 since the early 1990s, just a few years after it first invaded the island.
Rather than a red jumper, his tools of investigation have been a variety of molecular biology techniques, such as Sanger sequencing and restriction enzyme digests, which he has used to characterize the …
Recent developments in genome-editing technologies have turned the biotech industry's dream of mastering nature into a fast approaching reality. Want to change the color of an ear of corn? All you need to do is edit the relevant gene using the CRISPR/Cas system.
But some traits cannot be edited at the genomic level. The three ears of corn above may have strikingly different appearances, but they are genetically identical – varying only in their epigenomes.
Biotech strategies using genome engineering are impotent when it comes to epigenetically regulated phenotypes. Instead, epigenome-engineering tools are called for. And, as participants heard at May's meeting of the London Epigenomics Club, these prophesized epigenome-engineering tools are now a reality.
How to edit …
What do insects and geckos have in common? The answer, from the recent Royal Society conference on cell adhesion, is that their climbing mechanism depends on van der Waals forces (as well as friction and shear stress). However, at a structural and molecular level, the way they attach to surfaces is different. This was the focus of the conference – to understand the forces involved in cell adhesion, how geometry is important, and what we understand about adhesion at a molecular level.
Kevin Kendall (the main conference organiser) introduced the meeting by reminding everyone that it was 100 years since Ross Granville Harrison demonstrated that embryonic cells could be grown in culture outside of an organism – and …
Writing in 1945 on the role of models in biology, Arturo Rosenblueth and Norbert Wiener (founders of cybernetics, arguably a precursor of today’s systems biology) said, “The best material model for a cat is another, or preferably the same cat”. In a review in BMC Biology, Jeremy Gunawardena revisits the topic and confronts again the thorny issue of how to marry the elegance and precision of mathematical modeling to the messy reality of biology.
Gunawardena, who is a mathematician by training, provides a highly readable historical and personal perspective on how to approach models of biological systems for biologists. Currently, forward or reverse modeling are the two strategies described in the literature.
It is forward modeling that is the …
In our genomes, there is a whole host of genes hiding in plain sight. These genes are not included in major genome annotation efforts and are widely ignored in the literature, even though in some cases they have been conserved for as long as 550 million years.
So how have these genes remained hidden? There is a short answer to this. Literally so: the genes are short.
Scientists and computer algorithms that hunt for genes expect their prey to take the form of long sequences of hundreds of nucleotides, and quite simply ignore or discard candidates that do not meet this criterion.
But they are perhaps unwise to do so, suggest a number of recent reports, including an article in BMC …
You’re a conservationist with a list of threatened species and a limited budget. What are you going to save? Pandas or polar bears? Corals or condors? Leopards or leatherbacks? You have little time to deliberate, and you need a rational basis for your decision.
Performing phylogenetic triage
How to advise those in the unenviable position of making these decisions was the focus of a meeting on ‘Phylogeny, extinction risks and conservation’ last week at the Royal Society, where the central issue was how to exercise this kind of “phylogenetic triage” in the face of inevitable biodiversity loss.
We need some way to choose which species will …
The epidemiological evidence now seems overwhelming: obesity is a major cause of cancer, which will rise with the rising tide of obesity in the well fed Western world. Elio Riboli will speak on what epidemiology can tell us about how our physiology and habits contribute to the probability of developing cancer at the second BMC conference on Metabolism, diet and disease, and in an interview for BMC Biology he explained how perceptions have changed in the past ten years.
Red and processed meat have notoriously been incriminated in increased risk of cancer, an association recently confirmed by a paper in our sister journal BMC Medicine, with fruit and vegetables, long advocated for health and long …