Our readers might have gotten distracted this month by discussions on whether it is right or wrong for Illumina to limit researchers’ use of their kit, and so we are here to help you regain focus: after a deliberately thematic issue on the RBPome, we have just published an accidentally thematic issue on DNA methylation.
This month Genome Biology publishes three tools that many working on DNA methylation should find quite handy.
Mark Robinson (of edgeR, which he published together with another of this issue’s authors, Gordon Smyth) and company present a new method, BayMeth, for the effective quantification of data generated with DNA-methylation-capture-seq techniques (MBD-seq, MeDIP-seq and so on). So if you …
Do you feel you’re drowning in the dating scene? Have you suffered a string of failed relationships or flings? Is love a distant dream you are beginning to lose faith in? Well, cheer up, because if you think your life is lacking in romance, you should see how awful the animal kingdom can be. Here we show you how shallow, promiscuous, strange, and utterly dreadful creatures are when it comes to love. There’s the chance to vote for your favourite couples too (more details at bottom):
Strawberry Dart Frog – can’t handle being far apart:
“You’re, like, my perfect guy – you’re only 2 centimetres away from me!”
In a world where everyone is perfect, who would you pick? This is a dilemma …
Polycomb-group proteins are a well-characterized family of proteins involved in chromatin remodeling. In mammals, Polycomb-group proteins form two multiprotein complexes: Polycomb repressive complex 2 (PRC2), which represses gene expression, and PRC1.
PRC1, unlike its highly conserved sister, is a masterpiece of variety. It comprises the subunits Polycomb (Pc), Posterior sex combs (Psc), Polyhomeotic (Ph) and Sex combs extra (Sce) – but in humans there are five orthologs of Pc, six of Psc, three of Ph and two of Sce, which can, in theory, give rise to up to 180 different versions of PRC1. And while we don’t know for sure how many versions of PRC1 are to be found in human cells, one thing is clear: there doesn’t …
In 2012, Genome Biology joined with a number of other journals to publish articles describing the ENCODE project, which set out to catalog how proteins bind to the genome in order to regulate transcription. With a similar goal, we published a special issue focused on epigenomics, which looked at both DNA-bound proteins and epigenetic modifications to the DNA molecule itself, again with a view to better understanding the regulation of transcription.
Although we continue to publish many epigenomics articles, we were keen this year to turn our attention to a new frontier of gene regulation: the RBPome. Just as proteins bind DNA to regulate transcription, RNA-binding proteins (RBPs) bind to the transcriptome in order to regulate RNA …
Genome Biology would like to announce that we are now inviting Research, Method or Software manuscript submissions for publication in a special issue on cancer progression and heterogeneity, which is planned for late summer 2014.
Recent advances, such as single-cell sequencing technologies, are allowing us to study cancer genomics at a depth that was not previously possible. Now, Genome Biology wants to highlight the importance of this field by publishing a special issue with an emphasis on cancer progression and heterogeneity. We will consider Research, Method and Software manuscripts describing insights into, or developing methods for studying, all aspects of the genomics of cancer progression, including the clonal evolution of cancer, cancer heterogeneity, metastasis, single-cell …
Low amplitude vibrations produced by ‘twerking’ of the abdomen may prevent a premature and grisly end to the courtship efforts of male black widow spiders, are the findings of new research published in Frontiers in Zoology today. Female black widow spiders, which are notorious predators, with a low tolerance for intruders, are wooed by hopeful suitors who whisper these vibrations on entrance to their webs and thus may avoid being confused with prey items.
In order to investigate how male spiders signal their presence to a female, without appearing as prey, researchers from Simon Fraser University recorded the vibrations made by the black widow spider (Latrodectus hesperus) …
We are pleased to announce that Biological Research, the official journal of the Chilean Biology Society (Sociedad de Biología de Chile) has joined the BioMed Central portfolio in 2014.
Originally named Archivos de Biología y Medicina Experimentales, Biological Research was founded in 1964. For 49 years the journal has been dedicated to publishing articles across the scope of experimental biology. With an Impact Factor of 1.12, it is ranked second out of all Chilean journals.
The research focus of Biological Research’s Editor-in-Chief, Dr Manuel J. Santos (Pontificia Universidad Católica de Chile), is the biogenesis of cellular organelles, particularly peroxisomes. A pioneer in this field, he discovered a new type of human genetic disease, the peroxisomal …
Cilia have a checkered past when it comes to research. Some of these tiny, tail-like structures were once thought to have limited function and were largely ignored by the research community. Over the past two decades, however, new discoveries have radically changed that view.
The motile cilia fared better in this history, as their function was easier to decipher. Projecting from the outside of cells, motile cilia beat in waves and help to move the cell around (or move things around the cell). For example, in the human trachea, motile cilia help to sweep out dirt and mucus from the lungs.
On the other hand, primary cilia are found on almost every cell in the human body (as well …
Genome Biology today publishes the first set of articles in this month's special issue focused on 'the RBPome'. We will continue to publish RBPome articles throughout January, so look out for a heady mix of Research, Method, Software, Review, Research Highlight and Editorial articles.
'The RBPome' is our term for the rather wordy concept of 'RNA-binding proteins (RBPs) and their recognition elements within the transcriptome'. We hope to put the spotlight on gene regulation by RBPs, who until now have received less attention in the literature than gene regulatory components that act on DNA, such as transcription factors and histone modifications.
Who and what will be included in the issue?
One reason why the RBPome has been somewhat neglected is that …
A major focus of Genome Biology's RBPome issue is the role that RNA-binding proteins play in regulating splicing within the transcriptome.
But what are the triggers that cause these proteins to change their binding patterns, and so modify splicing programs? Might environmental cues such as light be responsible?
A new article published today in our RBPome issue suggests that this might very well be the case.
In the study, Shih-Long Tu and colleagues (Academia Sinica, Taiwan) use the moss Physcomitrella patens to report the first example of light-mediated splicing in plants.
The moss was exposed to different light conditions, following which high-throughput sequencing was employed to monitor changes in splicing. The sequencing data suggested that light induces a …