As next generation sequencing methods quickly become ubiquitous tools of genomics, more and more effort is directed to understand what are the limitations of these approaches. These limitations present themselves quite often in the form of coverage biases.
Last year Genome Biology published a study from David Jaffe and colleagues that looked at coverage biases in DNA sequencing. The authors used a suite of computational tools for bias assessment and applied them to a number of commonly used technologies. It turned out that, for instance, PacBio coverage is the least biased; and that high- and low-CG regions and long runs of homopolymers are very prone to coverage biases. They emphasized that the presence of such biases may lead to …
For almost thirty years, David Stern has been obsessed with the fact that male fruit flies ‘sing’ to females. His work on this problem, published today in BMC Biology, has got him thinking about reproducibility in science. In this guest post, he sets out his prescription to help scientists check whether research results are reliable
As an undergraduate at Cornell in 1985, I looked for a research problem that combined my interests in genetics, evolution, and behavior. Kyriacou and Hall had recently reported that the period gene, which regulates circadian rhythms, also controlled a rhythm of fruit fly courtship song and that evolution of period explained a species difference in this courtship song rhythm. This seemed …
Inexplicably absent from the current fad for Scandi-dramas is a mystery thriller set among the geysers, glaciers and Guðmundsdóttirs of Iceland.
One compelling candidate for filling this void is Prof Karl Gústaf Kristinsson, a medical microbiologist at Reykjavík's Landspitali University Hospital, and his quest to tell the story of the superbug PMEN2.
The pneumococcal detective
Prof Kristinsson has been on the case of Icelandic varieties of the multidrug resistant pneumococcus PMEN2 since the early 1990s, just a few years after it first invaded the island.
Rather than a red jumper, his tools of investigation have been a variety of molecular biology techniques, such as Sanger sequencing and restriction enzyme digests, which he has used to characterize the …
Research published today in our journal Flavour shows that food arranged to resemble famous artworks tastes better than food in a traditional or neat presentation. So we thought we’d get everyone to improve their meals with an art-inspired presentation.
Tweet your examples of art-inspired food presentation using the hashtag #ArtisticTaste, and let us know whether it’s made your mealtime more fun. We’ll be sharing our favourites on Twitter from @BioMedCentral, and collecting up more on our Facebook page.
Here at BioMed Central, we never shy away from a challenge, our crack team had a go at making some themselves. Once they’d had a little think about what they wanted to recreate and chosen their ingredients, we …
To create new materials that mimic the strength and flexibility of black widow spider silk and drugs based on its potent venom, we need a full list of the proteins involved and what they do. Two BMC Genomics papers published today make a start on this task. In this guest post, Jessica Garb, an author on both papers, talks about how she and the team took an inventory of the proteins in black widow spider silk and venom glands, and what this means for biomaterials and medicine.
Spiders are widely admired for two of their most fascinating adaptations: silk and venom production. The silks and venom of black widows (Latrodectus hesperus) are highly prized because of their impressive properties, …
What is the nature of the relationship between the brain and the gut? This is a question that has fascinated scientists and clinicians for decades, and there appears to be no simple answer to it. It seems the more research that is done on this topic, the more complex and extensive the interactions are found to be.
This communication between the endocrine and nervous systems has been termed the gut-brain axis (or brain-gut axis), and is thought to be involved in many regular functions and systems within the healthy body as well as in many diseases.
Today is World Digestive Health Day, and we’re marking the date with the launch of an article collection, bringing together research from a …
Recent developments in genome-editing technologies have turned the biotech industry's dream of mastering nature into a fast approaching reality. Want to change the color of an ear of corn? All you need to do is edit the relevant gene using the CRISPR/Cas system.
But some traits cannot be edited at the genomic level. The three ears of corn above may have strikingly different appearances, but they are genetically identical – varying only in their epigenomes.
Biotech strategies using genome engineering are impotent when it comes to epigenetically regulated phenotypes. Instead, epigenome-engineering tools are called for. And, as participants heard at May's meeting of the London Epigenomics Club, these prophesized epigenome-engineering tools are now a reality.
How to edit …
In this guest blog, Ann Van Soom, currently a Full Professor at the Faculty of Veterinary Medicine, Ghent University, Belgium, writes about male:female sex ratios, and comments on an article published today in BMC Genomics.
When I was a little girl, I asked my father whether there were more boys or girls in the world. “More boys,” he said. “Why?” I questioned him further, with some indignation at being referred to as the less common gender. He answered me with the slightly sexist phrase: “Because boys have to fight for the girls.”
Many years later I discovered he was right, and maybe even for the reason he claimed. The sex ratio of humans at birth is about 1.05 in favour …
Sleep has been dominating the news this week, in particular the topic of sleep quality. A good night’s sleep is often tough to achieve, and a bad night’s sleep can become truly damaging to our mental health if it happens repeatedly. But what exactly causes unsatisfactory sleep?
Sleep is a vital part of our lives, although we spend most of it unconscious. It’s the time to repair and recover after the day’s events, so it’s no wonder that sleep contributes to our mental health and wellbeing. Insomnia is not only frustrating but is linked to depression, irritability, and increased risk of heart disease. If you are managing to drift off to sleep, however, you still need to consider …
Ever since seeing this amazing computer reconstruction of moas on David Attenborough’s Life of Birds, I’ve been slightly obsessed by them. These giant birds seem to have died out in around 1400, hunted to extinction by the Maori who arrived on the island about a century before. There have been the odd unsubstantiated report of sightings, but I do suspect if there were six foot tall carnivorous birds running around New Zealand, we’d probably know about it. Attenborough’s computer reconstruction seems to be the nearest we’re likely to get to get to seeing these creatures.
But that hasn’t stopped scientists from finding out as much as they can, from the few moa bones we have. A new study in …