In recent years, the impact of mobile genetic elements
which can ‘jump’ from one genomic location to another, and in doing so bring
about genetic recombination and genome reorganization, has been revealed.
A new journal that launches today, Mobile DNA, will publish
articles that provide novel insight into the mechanisms and regulation of these
mobile elements, and also the implications of the genetic rearrangements for cellular
function and organism evolution.
The first published articles include a launch Editorial from
the Editors-in-Chief, several research articles, and a review of how
discoveries into the mechanisms of mobile DNA have informed evolutionary
theory in the 21st century.
Mobile DNA launches with Professors Nancy Craig,
BioMed Central has today submitted the following contribution to the US Office of Science and Technology Policy’s Policy Forum on Public Access to Federally Funded Research:
(see also OASPA’s contribution, also submitted today)
operates a commercially viable business as an open access publisher. Under our
publishing model, the costs associated with research publication are covered by
open access publication fees rather than by subscription revenue. We now
publish over 200 online journals operating on this model. These journals go
from strength to strength, and are highly ranked by journal citation metrics
such as Impact Factor. Open access journals such as Genome Biology, Malaria
Journal and BMC Systems Biology, to
name just a …
An 83-gene signature for cachexia in cancer patients suggests that preclinical models do not accurately reflect the biological processes of this disease in humans, according to research recently published in Genome Medicine.
Cancer cachexia affects up to half of all cancer patients. It causes severe tissue wasting and weight loss which is resistant to increased nutritional intake, and can hasten cancer-related death. The molecular mechanisms behind this disease are poorly understood, and have mostly been examined biochemically or in preclinical models.
In their article “Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia”, Timmons and colleagues describe RNA profiling of muscle from cancer patients who were defined as either weight-stable or weight-losing since becoming …
Disabilities associated with HIV infection are a real concern as they can make it difficult for HIV sufferers to participate fully in society. Disabilities can be physical, mental or involve sensory impairment and there is also evidence to show that people with existing disabilities are at a higher risk of contracting an HIV infection. Although these issues are of high importance, research in these areas has been sparse and so the series HIV/AIDS and Disability published by Journal of the International AIDS Society aims to raise awareness of these subjects and propose recommendations for the future.
In their introductory Editorial ‘Special theme on HIV and disability – a time for closer bonds’, Shirin Heidari and Susan Kippax highlight …
Cancer Cell International has recently been accepted for indexing by Thomson Reuters and is on course to receive its first impact factor in June this year. The journal, which is overseen by Editor-in-Chief Denys Wheatley, currently has an unofficial 2008 impact factor of 2.65. Cancer Cell International has also been accepted for inclusion in BIOSIS previews.
With this news, we are now expecting first impact factors for 18 of our journals this year and keenly anticipate the release of the Journal Citation Report in June.
Full details on indexing of all BioMed Central journals is available on our website.
Questionnaires are a valuable tool for gathering outcome data from patients enrolled in clinical trials. In a review published this week in Trials Dr Phil Edwards considers recent developments in the field of questionnaire design that may help investigators minimize bias, improve data completeness and maximize precision in estimating the effect of treatments.
Questionnaires in clinical trials: guidelines for optimal design and administration
Trials 2010, 11:2 (11 January 2010)
[Abstract] [Provisional PDF]
Investigators often rely upon principles of questionnaire development that are based predominately on expert opinion rather than empirical evidence. …
Silence, a new open access journal covering all aspects of genetic and epigenetic control mediated by RNA, has launched with Phil Zamore and David Baulcombe as Editors-in-Chief. Silence is supported by an outstanding international Editorial Board.
The first articles published in Silence today cover a range of RNA regulatory areas. Mueller et al describe the Solution structure of the Drosha double-stranded RNA-binding domain, while Dr Parker reviews the role of argonaute as a key component in RNA slicing, particularly in light of recent work by Patel et al.
Silence aims to become the
journal for the RNA silencing and non-coding RNA community, bringing
together researchers working on all model organisms, and from both
academia and …
As the era of personalised medicine and genomics evolves and the potential for better targeted treatments becomes a reality, the need to identify which individual treatments will benefit each individual patient is becoming imperative. One way to do this is to try and identify predictive gene signatures. This is what Rajski and colleagues have done in the article published this week in BMC Medicine; “IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients”, using cell lines to first develop the signature, and later validating their data in clinical patient samples.
In the accompanying commentary, Werner and Bruchim nicely outline the broader background to the article and explain the way in which Rajski …
New research by Samir Hanash, Ross Prentice and colleagues, recently published in Genome Medicine, suggests that the different proteomic effects of estrogen-alone and estrogen plus progestin treatments may explain the distinctive clinical effects of each therapy.
Hormone replacement therapy (HRT) acts as an artificial boost to women’s hormone levels, providing short-term relief from symptoms of the menopause. However, the Women’s Health Initiative trials found that postmenopausal HRT may be associated with some adverse conditions, such as venous thromboembolism and stroke, as well as with positives like reduced risk of fracture. Estrogen plus progestin therapy seems to have more unfavorable effects than estrogen-alone, but the biological basis for this clinical outcome is not well understood.
Samir Hanash and colleagues
International Journal of
Behavioral Nutrition and Physical Activity (IJBNPA) has
recently published its first thematic
series of articles presenting research on how mass communication
and social marketing affect levels of physical activity within a population.
With rising trends in obesity and the associated
health problems, exacerbated by a lack of physical activity, governments are
increasingly keen to address these issues by encouraging us to get active.
The series, ParticipACTION: Baseline research on the resurgence
of Canada’s physical activity social marketing leader, focuses on ParticipACTION, a
not-for-profit organization dedicated to inspiring and supporting active living
and sport participation for Canadians. Edited by Adrian Bauman and Mark
Tremblay, the articles address a range of aspects including an assessment of the