In drug addiction
research, it is well established that an enhanced response to novelty can
predispose certain individuals to addiction.
previously shown that rats, selectively bred to have an increased locomotor
response to novelty, display differences in the amount of cocaine they self-administer,
compared to rats bred to be less reactive. Not only do they ingest greater
doses of the drug, they also exhibit enhanced impulsivity due to lowered
factor that also puts individuals at increased risk for drug abuse is gender. Trend
analysis shows that, compared to men, women begin using cocaine at younger ages,
become addicted to it more quickly and also suffer more intense cravings during
periods of abstinence. A hormonal
Thomson Reuters have accepted Journal of Nanobiotechnology, the first fully open access journal in this burgeoning research area, for Impact Factor tracking. Journal of Nanobiotechnology is now tracked from Volume 9 (2011) and the high quality of the content is reflected by a predicted Impact Factor of 5.09.
In October 2010, Professor Fernando Patolsky (University of Tel Aviv) became the new Editor-in-Chief of the journal. Fernando has made seminal advances at the interface between nanoelectronics and biological systems, fostering a unique approach in electrical means for label-free detection of chemical and biological species, with unprecedented high sensitivity. At the beginning of 2011, Fernando was joined by Professor Ueli Aebi (University of Basel) as co-Editor-in-Chief. A pioneer of nanobiology …
Discovered in 1888, and introduced to generations of scientists during school lessons on mitosis, the centrosome is a small but essential organelle, organizing microtubules and regulating cell-cycle progression in animal cells. Previously overlooked, the key role of the centrosome in regulating both normal cell division and asymmetrical cell division is now becoming clearer. It is time the centrosome took centre stage, with a new, open access journal from BioMed Central – Centrosome Research is now accepting submissions.
Centrosome Research is an open access, online journal that publishes basic, applied and translational research on all aspects of the centrosome and its functional equivalents.
Recent years have seen an explosion of research in this field, and Centrosome Research provides …
Following its recent move to online-only publication, Arthritis Research & Therapy is the latest journal to relaunch on BioMed Central’s new website platform.
The new website is an improved look for the journal, providing an enhanced user experience for our authors and readers.
New features include:
Tabbed style browsing – navigate as you would in your usual web browser, quickly and conveniently
Editors’ picks – read selected research and review highlights on the journal homepage
Streamlined ‘My Arthritis Research & Therapy’ section – sidebar navigation allows you to edit preferences easily and collate your favourite manuscripts
The new and more modern platform will enable the journal to progressively add new functionality and we’re keen to receive your feedback to help make the most of …
The stem cell field is a highly exciting area for both basic and translational research. In light of this, Genome Medicine, with Guest Editor Stuart Orkin, is launching a series of review and comment articles highlighting the most important and topical issues – the recent breakthroughs, controversies, challenges and medical implications – in stem cell research.
Genome Medicine’s thematic series on stem cell genomics will be presented together with related, specially commissioned content from two of our sister journals. The more basic biological aspects of stem cell biology will be covered by BMC Biology, while BMC Medicine is focusing on the efforts currently underway to take stem cell therapies to the clinic.
Genome Medicine is now seeking submissions of …
PMC Biophysics has this week re-launched in its new format as BMC Biophysics with an expanded scope and Editorial Board. The ‘P to B’ transition is the consequence of integrating PhysMath Central journals into existing Springer and BioMed Central portfolios which has resulted in this very welcome addition to the BMC series.
As part of the BMC series, BMC Biophysics will “fill its own niche in the BMC series alongside BMC Bioinformatics, BMC Medical Physics, BMC Structural Biology and BMC Systems Biology”, says Elizabeth Moylan, BMC-Series Editor for Biology, in her editorial.
BMC Biology, the flagship biology journal of the BMC series, marks the recruitment of the journal to the series …
Haematopoiesis, the process by which phenotypically distinct mature cells are generated from multipotent blood stem cells, is one of the best understood models of adult stem cell development and differentiation.
In their recently published review in Stem Cell Research & Therapy, Bertie Göttgen’s group from the University of Cambridge discuss the transcriptional regulation of haematopoetic transcription factors. Transcription factors directly regulate gene expression and play key roles in stem cell maintenance, lineage commitment and differentiation; they are powerful regulators of normal development and their misexpression has previously been found to cause leukaemia. The authors review recent studies that have identified specific regulatory codes within multiple modular regulatory regions in the genome, and how tissue-specific expression is mediated by …
Social science has
an important contribution to make to the understanding of globalization, its
dynamics, and its consequences for health equity and well-being, health systems
and the healthcare economy.
A new thematic series, Health
systems, health economies and globalization: social science perspectives,
published in Globalization and Health brings together articles that reflect
current developments within a range of social science disciplines contributing
to this area of enquiry. The collection aims to highlight challenges faced
in researching globalization, health systems and health economies and identify innovative approaches to
inform current research, health policy and organization.
New articles will be
added to the series soon; you can sign up to receive article alerts when
they are …
In this month’s issue of Genome Biology, Igor V. Grigoriev, Adam Kuspa and colleagues present the genome of Dictyostelium purpureum, a close relative (by around 400 million years) of Dictyostelium discoideum, the model Dictyostelid.
Until relatively recently, these interesting organisms were commonly known as slime molds; however they have now been classified as bona fide Amoebozoa. Dictyostelids are studied primarily to understand the evolution of multicellularity, because they exist in both single-celled and multicellular states. When nutrients are lacking, single celled organisms group together, forming multicellular ‘fruiting bodies’ with terminally differentiated spores. How this process works is still under investigation.
Kuspa and colleagues have sequenced the genome of D. purpureum and compared it to that of D. discoideum. They …
To correctly interpret claims made in the medical literature, the reader must understand the statistical significance testing that underpins them. There are concerns, however, that many physicians misunderstand the probabilistic logic underlying these tests. As well as having a potentially negative effect on the quality of medical research, this lack of understanding could ultimately have adverse implications for public health.Westover and colleagues highlight and attempt to address this problem in their debate published today in BMC Medicine.
By administration of a simple quiz to 246 physicians, Westover et al. found that a startling 93% answered incorrectly. In light of these results, the authors provide an accessible explanation of the underlying probabilistic concepts that need to be followed if intelligent …