The WHO minimum dataset has improved trial registry compliance but many individual trial records recorded between April 2005 and February 2007 still omit key information, including researcher contact details, a study published this week in Trials has found.
The registration of clinical trials in a publicly accessible database has become an established part of the research process for healthcare interventions, and is also increasingly accepted on ethical and moral grounds. The most recent revision to the Declaration of Helsinki – in October 2008 – included a requirement for prospective trial registration.
Since 2005 the ICMJE has required that trials be registered in compliance with the 20-item WHO minimum dataset – “The minimum amount of trial information that must …
“Genomic advances and their impact on clinical trial design”, a Commentary published this week in Genome Medicine, discusses the effect current advances in genomic research have on the future of clinical trial design and on the interpretation of clinical trial data for disease management.
In their article, Dr Sumithra J Mandrekar and Dr Daniel J Sargent highlight milestones in genomic advances, such as the ability to develop genomic signatures for risk stratification of patients with various diseases and the development of biomarkers indicating how a particular patient might respond to treatment.
Although these advances have been hugely beneficial to medical research, their increased validity has given cause for a whole new way of designing clinical trials in …
After review by the Literature Selection Technical Review
Committee, the following three journals have been accepted for inclusion in MEDLINE, the
National Library of Medicine’s premier bibliographic database:
BMC Medical Genomics
BMC Oral Health
Microbial Cell Factories
Inclusion of these journals in MEDLINE is a strong
endorsement of the journal’s growing reputations in their fields, and we would
like to congratulate the Editorial Teams of each of these journals. For BMC Medical Genomics this achievement comes on
the back of the news that the journal has recently
published its 100th article.
All BioMed Central journals are indexed/included
in PubMed, PubMed Central, Scirus, Google Scholar, Citebase, OAIster and
Scopus, with growing numbers of journals in Thomson Reuters, Medline, CABI …
Many learned societies are considering the publishing strategies for their journals in the face of the squeeze on library subscriptions. Open access is an increasingly attractive option for many societies, providing a sustainable financial model for their journal, while helping to maximize the visibility of research in the field they support. BioMed Central currently has publishing partnerships with more than 30 societies which either started new open access journals or converted their previously subscription-based journals.
To ensure that societies have the facts to hand when making their decisions, BioMed Central recently hosted a workshop for a group of consultants who advise societies. The presentations from the day are now available, covering the history and current workings of open access at …
This month, NHS England became a Supporter Member of BioMed Central.
This means that all researchers, practitioners and students working
within the NHS in England will benefit from a 15% discount on
publication fees when publishing the results of their research in one
of BioMed Central’s 200 peer-reviewed open access journals.
The UK Department of Health, responsible for NHS England, has been a
strong advocate of increased access to the results of research,
participating in the UK PubMed Central open access digital archive
project and in 2007 introducing an official policy in support of open access.
NHS England researchers already publish hundreds of open access articles
each year in BioMed Central’s journals, including the ones …
Alzheimer’s Research & Therapy, a new BioMed Central journal edited by Douglas Galasko, Todd Golde and Gordon Wilcock has just published its first articles online.
The Editors-in-Chief introduce the journal in their editorial and to celebrate its launch, we will be distributing a special print preview issue at the Alzheimer’s Association 2009 International Conference on Alzheimer’s Disease (ICAD, booth 119; Vienna, 12th – 15th July). Please come along and pick up a free copy if you are attending this meeting.
The journal aims to be the major forum for translational research into Alzheimer’s disease (AD) and will publish open access research articles of exceptional interest. Review articles and expert commentary will accompany key papers.
Our first articles include a
Arthritis Research & Therapy is unveiling a new look in the latest print edition of the journal. This bi-monthly issue – now in its 11th volume – presents a compendium of content found on the journal website, where articles are continuously published.
The June print issue introduces a colourful new front cover design, and an Editors’ Choice page that highlights articles of special interest as selected by the Editors-in-Chief. Subscribers will also receive a bumper edition of the journal containing six authoritative review articles on topics such as spondylarthritis, gout and systemic lupus erythematosus.
Arthritis Research & Therapy is an international, peer-reviewed journal with a focus in mechanisms of, and translational laboratory and clinical research into localised and systemic immune-inflammatory and …
Professor David Baulcombe, co-Editor-in-Chief of Silence,
has been awarded a Knighthood for his services to plant science. David is
Professor of Botany and Royal Society Research Professor at Cambridge
University. His research interests include RNA silencing and protein-based
innate immunity mechanisms in plants against pests and disease.
a new open access journal soon to be launched by BioMed Central, covers all
aspects of genetic and epigenetic control that is mediated by RNA. David, and
his co-Editor-in-Chief Phillip Zamore (Gretchen Stone Cook
Professor of Biomedical Sciences, University of Massachusetts Medical School,
USA), are supported by an expert Editorial Board. For
more information about Silence please visit the journal website, where you can also sign up
for regular updates …
“Exploring the unknown: assumptions about allelic architecture and strategies for susceptibility variant discovery”, a Minireview published this week in Genome Medicine, highlights the significant progress in identifying the genomic mechanisms behind disease predisposition.
In his article, Prof Mark I McCarthy explains that, although the discovery of specific genes associated with many common diseases is interesting, there are still many unanswered questions regarding the best way to identify predisposition to disease.
Genome-wide association studies help to identify a small proportion of common variants associated with a specific disease. Prof McCarthy highlights the importance of understanding the effect of allelic architecture within the identified genes, and discusses how future research prospects of combining data from common-variant associations with structural genetic …
Last week BioMed Central exhibited at the 17th International Conference on Intelligent Systems for Molecular Biology (ISMB) & 8th European Conference on Computational Biology (ECCB) in Stockholm, where 1,400 delegates descended upon Stockholm International Fairs.
ISMB/ECCB is a great opportunity for us to meet with researchers who have published in our bioinformatics journals, such as BMC Bioinformatics and BMC Systems Biology. Many delegates were excited to see our new Impact Factor of 3.71 for BMC Systems Biology and the imminent launch of our latest independent journal, Journal of Biomedical Semantics.
Perhaps the biggest highlight of our time at the conference was the Sudoku challenge on Thursday morning where delegates raced each other to finish a Sudoku puzzle …