Henk Moed at the Centre for Science and Technology
Studies (CWTS) at Leiden University has recently developed
a new journal indicator, the Source Normalized Impact per Paper (SNIP), based
on citation data from Scopus. A journal’s
SNIP can be thought of as similar to a normalized Impact Factor, which weights citations to adjust
for the fact that some fields are more citation-rich than others. The intention
is that SNIPs will allow more effective comparison of journals between
different fields. More
information about SNIPs and how they are calculated can be found in Moed’s recent article
and at www.journalindicators.com.
Orphanet Journal of Rare Diseases is BioMed Central’s highest-ranking journal based
on the SNIP metric, with a …
Genome Biology recently published an article from Alicia Oshlack and colleagues in which they describe an approach for performing Gene Ontology analysis on RNA-seq data. RNA-seq is an emerging technology for monitoring gene expression levels by directly sequencing the mRNA molecules in a sample, and is likely to overtake microarrays as the technique of choice for gene expression profiling. Now, Genome Biology has published another innovative method, this time for normalizing RNA-seq data. This method is much needed and will be embraced by the genomics community as, until now, methods for normalizing RNA-seq data have often relied on tools that were based on those developed for microarray data.
A common approach for normalizing RNA-seq data has been …
Research recently published in Genome Medicine shows that a widely-accepted model for predicting genetic risk of disease is not realistic when it is applied to current human disease data. Three other models provide a better fit to these data but are indistinguishable from each other.
Naomi Wray and Michael Goddard, from Queensland Institute of Medical Research and the University of Melbourne, examined mathematical models which integrate the disease risks from several genomic loci to determine the overall risk to an individual.
The unconstrained Risch model, which is commonly used in theoretical studies, was rejected as being unrealistic according to current human complex disease parameters. However, the CRisch, Odds, and Probit models were all compatible with these observed data. …
Neural Systems & Circuits, a new open access journal focusing on systems and computational neuroscience, is now accepting submissions.
Neural Systems & Circuits aims to publish exciting research on how individual neurons interact at the network level to perform interesting computations, and welcomes studies combining theory and experiment, reports of technical or analytical innovations and large-scale genetic or connectomic studies.
This new BioMed Central journal is overseen by co-Editors-in-Chief Peter Latham (Gatsby Computational Neuroscience Unit, UCL, UK) and Venkatesh Murthy (Harvard University, USA), who are supported by an expert Editorial Board
For more information on Neural Systems & Circuits, please visit the journal website or contact the Editorial Office. Why not register for updates keeping you abreast of …
The International Symposium on Intensive Care Medicine (ISICEM) is an annual event open to all intensivists and clinicians working in the critical care field, and is celebrating its 30-year anniversary this March. To mark this occasion, Critical Care is giving delegates a unique opportunity to meet Editor-in-Chief and ISICEM chairman Prof Jean-Louis Vincent, and ask him any question about the journal, and the critical care field.
To take part in this event, please contact ISICEM@ccforum.com to express your interest and submit your question to Prof Vincent.
Critical Care Meet the Editor Event:
Thursday 11 March 2010
17:00 – 18:00pm
Whether you’re asking a question or listening to the answers, please come along and be a part of the …
In a systematic review published this week in Trials, Simpson and colleagues investigate techniques and interventions to reduce inappropriate enrollment of patients into clinical trials. Key
eligibility criteria ensure the exclusion of patients likely to be harmed by treatments,
and enrollment of patients in violation of these criteria can result in
avoidable harm including serious adverse events and death.
systematic review of techniques and interventions for improving
adherence to inclusion and exclusion criteria during enrolment into
randomised controlled trials
Fiona Simpson, Elizabeth A Sweetman, Gordon S Doig
Trials 2010, 11:17 (23 February 2010)
[Abstract] [Provisional PDF]
A search of the literature uncovered only one abstract describing an intervention designed to reduce …
The rate at which Alzheimer’s disease progresses varies greatly between patients. Clinicians are often asked by patients and their families to predict the rate of decline, however there is currently little data available to base such predictions on. In research published in Alzheimer’s Research & Therapy this week, Doody et al. have used a simple, calculated progression rate at initial visit to predict future performance of patients at assessments of cognition and activities of daily living.
progression of Alzheimer’s disease
Today an annotation of the pea aphid immune system has been published in Genome Biology by Nicole Gerardo and colleagues. This coincides with the publication of the draft pea aphid genome sequence from the International Aphid Genomics Consortium in PLoS Biology.
Due to its unusual process of metamorphosis the pea aphid provides interesting insights into insect development and, as a major vector of plant viruses and cause of crop damage, further understanding of pea aphid biology may lead to the development of control strategies. Pea aphids also display other fascinating biological properties, such as phenotypic plasticity, a lifecycle that alternates between parthenogenic and sexual reproduction, and they have co-evolved with symbiotic bacteria.
In their Genome Biology …
The launch of Molecular Autism today provides autism researchers with a new forum for basic, translational and clinical study into the molecular basis of autism and related neurodevelopmental conditions.
In their lead
editorial, Editors-in-Chief Joseph Buxbaum (Mount Sinai School of Medicine)
and Simon Baron-Cohen (University of Cambridge) present Molecular Autism’s mission
statement. The journal’s unique
molecular focus is key to identifying the fundamental determinants of autism
and achieving one of our primary goals – correcting the bias towards psychological
study that has characterized the past 60 years of autism research. Through Molecular Autism, the Editors hope to
tackle the multi-level complexity of autism and related syndromes by
engendering greater …
Today BioMed Central announces the launch of ‘Beyond the Genome: The true gene count, human evolution and disease genomics’, an international conference which brings together leading researchers and industry representatives from around the globe.
The conference, organised by BioMed Central, marks Genome Biology’s 10th anniversary and the recent launch of its sister journal Genome Medicine.
At the conference, internationally renowned researchers will deliver cutting edge presentations in key areas of post-genomic research in biology and medicine and future developments, including the Human Microbiome Project and the resequencing of matched tumour and normal genomes from specific types of cancers.
The event is taking place between 11-13 October 2010 in Boston, Massachusetts. The organising committee includes Elaine Mardis from the Washington …