In a recent report, Zheng et al demonstrate a technique for the specific inhibition of miRNA expression in Caenorhabditis elegans using modified antisense oligonucleotides, which could be utilized as a potent tool for the study of regulation and function of miRNAs in vivo. Their article is published in Silence, and is discussed further in a mini-review by Slack et al, published in Journal of Biology.
The authors developed a new class of fluorescently labeled antisense reagents in order to specifically inhibit the function of miRNAs in C. elegans. These antisense oligonucleotides were introduced into the germline of adult hermaphrodite C. elegans and passed onto the worms’ progeny, and were successfully shown to efficiently and specifically inhibit Lin-4 …
The zebra finch joins the chicken today as the second bird species to have its genome fully sequenced. The abilities of this bird to learn songs makes the zebra finch an attractive species to study the neurobiology and evolution of learned behavior. Songbird studies will also shed light on cognitive processes involved in vocal communication and related aspects of brain development and evolution.
With the announcement of the full genome sequence, BioMed Central launches an exciting new thematic series, bringing together zebra finch related research across our journals.
In Journal of Biology, Raphale Pinaud highlights some of the new insights and areas of study that profit from …
Journal of Biomedical Semantics was launched today, aiming to address the barriers to access and integration of data in the public domain that can hinder reanalysis. Semantics are essential for mining and analyzing data and the ability to manage semantic representations is vital for making computational approaches productive for a large community. The first articles published in the journal today reflect this.
In their introductory editorial ‘BioMedical Semantics: the hub for Biomedical Research’ Dietrich Rebholz-Schuhmann and Goran Nenadic discuss the importance and history of biomedical semantics as an emerging field and examine the aims of this timely new journal. Also published today, Dr Nigel Collier addresses the issue of systematically evaluating online health news to support …
Behavioral & Brain Functions, Molecular Brain and Particle and Fibre Toxicology have recently been accepted for inclusion in MEDLINE bringing the number of BioMed Central journals indexed in MEDLINE to a total of one hundred. This news is an endorsement of the success of each of these journals and reflects the strong reputations they have built in their respective fields.
In June of this year Behavioral & Brain Functions will also receive its first impact factor, which we eagerly anticipate. Particle and Fibre Toxicology is also tracked by Thomson Reuters and will be receiving its first impact factor in June 2011. Molecular Brain was launched just under two years ago with BioMed Central and has rapidly developed …
The CONSORT 2010 statement was co-published today by eight journals, including the BioMed Central titles Trials and BMC Medicine. Like the original statement published in 1996, the revised guidelines are intended to improve the reporting of randomized controlled trials by providing a checklist of essential items for use by authors, reviewers and editors. The latest revision draws on new evidence and experience gained since the last update in 2001.
CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials
Kenneth F Schulz, Douglas G Altman, David Moher, Consort Group
Trials 2010, 11:32 (24 March 2010)
[Abstract] [Provisional PDF]
In a commentary published today in Trials, Hywel Williams identifies the key additions to …
BMC Research Notes was launched with the aim of reducing the loss suffered by science (and the potential for publication bias) when sound research goes unpublished. Now, with a welcomed change to our formatting criteria even more "dark data" will be freed.
Since the journal focuses on short reports, small-scale confirmatory studies, negative results, incremental updates to previous work and data-driven publications, we originally envisaged that the vast majority of articles published would be short, less than 2000 words long with up to 30 references.
As the popularity of the journal grows, researchers are increasingly considering BMC Research Notes for full research articles and we are keen to save a valuable resource – our authors’ time and effort. Anecdotally, …
This week in Trials McKenzie and colleagues present their experience of obtaining ethical approval for a methodological study that planned to compare ethics committee applications with the published results of randomized controlled trials.
Obstacles to researching the researchers: A case study
of the ethical challenges of undertaking methodological research investigating
the reporting of randomised controlled trials
Joanne E McKenzie, G PETER Herbsion, Paul Roth, Charlotte
Trials 2010, 11:28 (21 March 2010)
The authors aimed to assess the prevalence of selective outcome reporting – where significant results are more likely to be reported than those that are not significant – but approval was denied on the grounds that they did not plan to obtain informed consent from trialists to view …
The publication of the first articles in Stem Cell Research & Therapy today marks the launch of a major forum for translational research into stem cell therapies.
Stem cell research has progressed to the clinic and has enormous potential for treating incurable diseases such as Parkinson’s disease and Alzheimer’s disease, and potential for alleviating suffering in chronic conditions such as diabetes and osteoarthritis.
This new journal is edited by Profs Rocky Tuan (University of Pittsburgh School of Medicine) and Timothy O’Brien (National University of Ireland, Galway), who welcome contributions in their lead editorial.
“The journal provides an important avenue of publication in translational aspects of stem cell therapy spanning preclinical studies, clinical research and commercialization. The critical pathway to the clinic …
association studies (GWASs) published in the last two years have confirmed the
role of APOE as a genetic risk-factor
for late-onset Alzheimer’s disease as well as proposing a host of other
potential candidate genes. However, despite their success in revealing common
genetic factors for complex diseases, it is unclear whether GWASs are able to
identify the underlying genetics of Alzheimer’s disease.
a review published recently in Alzheimer’s
Research & Therapy, Ertekin-Taner summarises genetic studies
in Alzheimer’s disease carried out before the GWAS era as well as findings from
recent GWASs and suggests that alternative approaches are necessary in order to
identify the remaining genetic susceptibility factors associated with the
disease. In particular, …
David Kelley and Steven Salzberg at the University of Maryland have developed a pipeline to correct misassembles due to false duplications, in a study published today in Genome Biology. Diploid genomes harbour a significant amount of variation between homologous chromosomes. This causes problems for genome assembly algorithms which may construct two DNA sequences corresponding to one divergent region and incorporate both into an assembly as a false segmental duplication.
Their approach is to align DNA sequence fragments to the surrounding sequence, using mate pair information, to determine whether duplicated segments should be merged into one copy. Mate pairs are two sequence reads derived from the same region of DNA and this study is the first time …