Nanoparticles embedded with drugs can cross the blood-brain barrier (BBB) and could be used to treat Alzheimer’s disease, according to a cell-based study published in the journal Alzheimer’s Research and Therapy today. The results of this study demonstrate nanoparticles are a promising tool to transport drugs to the brain for use in neurological conditions.
Alzheimer’s disease, one of the most common forms of dementia, is associated with pathological deposits of the amyloid-beta protein in the brain. Blocking the accumulation of amyloid-beta is thought to be one potential way of slowing the onset of the disease .
There have been many examples where clinical trials using anti-inflammatory drugs, which lower amyloid-beta levels to treat the disease, have failed. It …
There is conflicting evidence on whether high adiposity (shown physically as being overweight or obese) causes Alzheimer’s disease (AD). In a new debate published in Alzheimer’s Research & Therapy today, Deborah Gustafson (State University of New York, USA) and José Luchsinger (Columbia University, USA) review the evidence for and against this controversial association.
Some of the most convincing evidence for an association is from studies of mid-life risk factors. Some epidemiologic studies show that a high BMI, or central obesity, in mid-life is a risk factor for dementia, with an association measured at least a decade prior to a clinical dementia diagnosis. Biological evidence also supports high adiposity as an independent risk factor for …
Posted on behalf of Abigail Jones
How can people with rheumatic and musculoskeletal diseases enjoy an optimal quality of life?
This is the topic addressed by campaigns and activities forming part of World Arthritis Day, which will be marked on Saturday 12th October. This day, which was established in 1996 by Arthritis and Rheumatism International, aims to raise awareness of the issues affecting people with rheumatic and musculoskeletal diseases (RMDs) and to ensure all people with RMDs and their caregivers are alerted to the vast support network available to them.
Over the next year the World Arthritis Day website, which is supported and managed by EULAR (the European League Against Rheumatism), will be running a series of …
Clinical trials in Alzheimer’s disease (AD) are under enormous pressure to produce results, as there have been no new successful AD drugs in recent years. A large multi-centre study published in Alzheimer’s Research & Therapy identifies an important issue in AD clinical trials; that participants that have been on acetylcholinesterase inhibitor (ChEI) treatment for mild AD may skew results when included in a study for a new drug.
Currently, the main treatment for mild-to-moderate AD is ChEIs, which include donepezil, rivastigmine and galantamine. These have been shown to have positive symptomatic effects on cognition and function and act by improving neuronal communication by preventing acetylcholine (ACh) degradation. Levels of ACh in the synaptic cleft of …
Alzheimer’s Research & Therapy is accepting research submissions for consideration in a special series on immunotherapy in Alzheimer’s disease.
Accumulation of amyloid-beta protein (Aβ) and hyperphosphorylated tau protein are the pathological hallmarks of Alzheimer’s disease (AD), the most common form of dementia. The current approved therapies for AD consist of symptomatic treatments, which do not slow down the underlying disease process. Therefore, in the past decade, research has been heavily focussed on finding ‘disease modifying drugs’ that will counteract the progression of AD by intervening in a specific part of the neuropathology.
Immunotherapy has been the most extensively studied approach in Aβ-targeted therapy, and both passive and active immunotherapies have been shown to effectively reduce Aβ pathology in preclinical models. Comparatively, …
If there were an early medical test for Alzheimer’s disease (AD), would you choose to take it? Most adults would, suggests a study in the open access journal Alzheimer’s Research & Therapy. The potential repercussions of this could be high, with medical, political and legal ramifications.
Alzheimer’s disease is the most common type of dementia, a chronic, neurodegenerative disease without a cure. Early detection, before symptoms have set in, could broaden the window for therapeutic intervention, and current attempts to devise reliable, predictive tests appear promising.
Elizabeth Wikler and colleagues have conducted the first large, international, randomized public survey of interest in the possibility of early medical testing for AD. More than 2,500 randomly-selected adults from the United States, France, …
Dementia is seen as one of the main health and social care challenges of the 21st century. As a result of increasing life expectancy, there is no other disease area where the number of people affected is going up so rapidly. National dementia plans are needed to prevent a huge strain being placed on healthcare authorities to provide quality care to this increasing population.
September is World Alzheimer’s Month and this year’s theme is “Dementia: a journey of caring”. The focus is on the care required by people with dementia throughout the course of their condition.
Alzheimer’s Research & Therapy is marking the occasion by publishing a special commentary by Marc Wortmann on the importance of national plans for Alzheimer’s …
Alzheimer’s Research & Therapy is accepting research submissions for consideration in a special series on tau-based therapeutic strategies for Alzheimer’s disease and related dementias.
There is great interest in finding therapeutics to reverse or remove tau aggregates from the human brain. Pathological aggregation of tau protein is associated with many neurodegenerative diseases, termed ‘tauopathies’, the most common of which is Alzheimer’s disease. However, there is currently only one drug entering phase III clinical trials for treating tauopathies (read more about these clinical trials here).
This series aims to evaluate the current tau-based strategies developed to date, and to discuss new research directions and recommendations that will accelerate preclinical and clinical development of future therapies.
The publication of research …
In September last year, the National Football League (NFL) pledged to provide $30 million in funding for medical research, the single-largest donation to any organization in the league’s 92-year history.
One of the main research areas for the funding, overseen by The National Institutes of Health (NIH), is chronic traumatic encephalopathy (CTE) and the link with neurodegeneration, especially Alzheimer’s disease.
CTE is a progressive degenerative disease of the brain found in people with a history of repetitive brain trauma. This condition has emerged as a significant public health problem, particularly among those in the military or athletes involved in contact sports such as boxing, American football and soccer.
Alzheimer’s Research & Therapy is inviting research submissions to …
Accelerating the development of innovative treatments for Alzheimer’s disease and related dementias is the target for scientists brought together at the 14th International Conference on Alzheimer’s Drug Discovery, and the focus of a special thematic series in Alzheimer’s Research & Therapy.
Hosted by the Alzheimer’s Drug Discovery Foundation (ADDF), on 9 – 10 September 2013 in Jersey City, USA, academic and industry scientists will attend the annual conference to highlight scientific progress on drug discovery programs aimed at treating Alzheimer’s disease and related dementias, as well as forming partnerships with fellow researchers.
Early bird registration ends this Friday, 9th August – don’t miss out!
ADDF is a public charity supporting the advancement of drugs to prevent, treat, and cure Alzheimer’s …