Substantial progress has been made in the targeted therapy of breast cancer, with three new targeted therapies licensed for advanced breast cancer over the last two years. Targeted therapies block the growth and spread of cancer by interfering in specific biological processes responsible for cancer cell growth. Therefore targeted therapies may be more effective and less harmful to normal cells than other cancer treatments, such as traditional chemotherapy that targets all rapidly dividing cells. The most well known targeted therapy at the moment is trastuzumab (Herceptin).
A new thematic series in Breast Cancer Research brings together the translational research behind these new approaches, as well as reviewing treatments with early evidence of efficacy that are still …
One of the commitments from the recent G8 dementia summit held in London in December 2013, was to support countries to strengthen health and social care systems, with the aim to improve care and services for people with dementia.
A research article, published today in open access journal Alzheimer’s Research and Therapy, shows that a care coordination programme for patients with Alzheimer’s disease and their carers resulted in improvements in psychosocial function of people with dementia. The programme, a partnership between community and health organisations, also showed positive results for carers.
The programme, called Partners in Dementia Care (PDC), is a partnership between healthcare and community agencies that provides care coordination for medical and non-medical needs of both patients …
This week, the National Institutes of Health (NIH), 10 biopharmaceutical companies and several non-profit organizations launched an unprecedented partnership to transform the current model for identifying and validating the most promising biological targets of disease for new diagnostics and drug development.
Currently in the US, developing a drug from early discovery through Food and Drug Administration (FDA) approval takes well over a decade and has a failure rate of more than 95%. As a consequence, each success can cost $1 billion or more. It was therefore recognised that new approaches were required, and that collaborative efforts might be a way to increase the collective odds of success.
Through the Foundation for the NIH, the Accelerating Medicines Partnership (AMP) will invest …
Alzheimer’s Research & Therapy is now accepting research submissions for consideration in a special series on Lewy body dementia, planned for publication in mid-2014.
The publication of these articles will be co-ordinated with a series of commissioned reviews and opinions, guest edited by co-Series Editors Prof Ian McKeith (Newcastle University, UK) and Prof James Galvin (NYU, USA), and written by leaders in the field including John O’Brien (Cambridge University, UK), Brit Mollenhauer (Paracelsus Elena Klinik, Germany) and Glenda Halliday (Neuroscience Research Australia).
Lewy body dementia (LBD) is the second most frequent cause of dementia after Alzheimer’s disease, affecting approximately 4 million people globally. LBD consists of two related syndromes: dementia with …
Nanoparticles embedded with drugs can cross the blood-brain barrier (BBB) and could be used to treat Alzheimer’s disease, according to a cell-based study published in the journal Alzheimer’s Research and Therapy today. The results of this study demonstrate nanoparticles are a promising tool to transport drugs to the brain for use in neurological conditions.
Alzheimer’s disease, one of the most common forms of dementia, is associated with pathological deposits of the amyloid-beta protein in the brain. Blocking the accumulation of amyloid-beta is thought to be one potential way of slowing the onset of the disease .
There have been many examples where clinical trials using anti-inflammatory drugs, which lower amyloid-beta levels to treat the disease, have failed. It …
There is conflicting evidence on whether high adiposity (shown physically as being overweight or obese) causes Alzheimer’s disease (AD). In a new debate published in Alzheimer’s Research & Therapy today, Deborah Gustafson (State University of New York, USA) and José Luchsinger (Columbia University, USA) review the evidence for and against this controversial association.
Some of the most convincing evidence for an association is from studies of mid-life risk factors. Some epidemiologic studies show that a high BMI, or central obesity, in mid-life is a risk factor for dementia, with an association measured at least a decade prior to a clinical dementia diagnosis. Biological evidence also supports high adiposity as an independent risk factor for …
Posted on behalf of Abigail Jones
How can people with rheumatic and musculoskeletal diseases enjoy an optimal quality of life?
This is the topic addressed by campaigns and activities forming part of World Arthritis Day, which will be marked on Saturday 12th October. This day, which was established in 1996 by Arthritis and Rheumatism International, aims to raise awareness of the issues affecting people with rheumatic and musculoskeletal diseases (RMDs) and to ensure all people with RMDs and their caregivers are alerted to the vast support network available to them.
Over the next year the World Arthritis Day website, which is supported and managed by EULAR (the European League Against Rheumatism), will be running a series of …
Clinical trials in Alzheimer’s disease (AD) are under enormous pressure to produce results, as there have been no new successful AD drugs in recent years. A large multi-centre study published in Alzheimer’s Research & Therapy identifies an important issue in AD clinical trials; that participants that have been on acetylcholinesterase inhibitor (ChEI) treatment for mild AD may skew results when included in a study for a new drug.
Currently, the main treatment for mild-to-moderate AD is ChEIs, which include donepezil, rivastigmine and galantamine. These have been shown to have positive symptomatic effects on cognition and function and act by improving neuronal communication by preventing acetylcholine (ACh) degradation. Levels of ACh in the synaptic cleft of …
Alzheimer’s Research & Therapy is accepting research submissions for consideration in a special series on immunotherapy in Alzheimer’s disease.
Accumulation of amyloid-beta protein (Aβ) and hyperphosphorylated tau protein are the pathological hallmarks of Alzheimer’s disease (AD), the most common form of dementia. The current approved therapies for AD consist of symptomatic treatments, which do not slow down the underlying disease process. Therefore, in the past decade, research has been heavily focussed on finding ‘disease modifying drugs’ that will counteract the progression of AD by intervening in a specific part of the neuropathology.
Immunotherapy has been the most extensively studied approach in Aβ-targeted therapy, and both passive and active immunotherapies have been shown to effectively reduce Aβ pathology in preclinical models. Comparatively, …
If there were an early medical test for Alzheimer’s disease (AD), would you choose to take it? Most adults would, suggests a study in the open access journal Alzheimer’s Research & Therapy. The potential repercussions of this could be high, with medical, political and legal ramifications.
Alzheimer’s disease is the most common type of dementia, a chronic, neurodegenerative disease without a cure. Early detection, before symptoms have set in, could broaden the window for therapeutic intervention, and current attempts to devise reliable, predictive tests appear promising.
Elizabeth Wikler and colleagues have conducted the first large, international, randomized public survey of interest in the possibility of early medical testing for AD. More than 2,500 randomly-selected adults from the United States, France, …